Sulfadoxine

Modify Date: 2024-01-04 15:54:57

Sulfadoxine structure	Common Name	Sulfadoxine
	CAS Number	2447-57-6	Molecular Weight	310.329
	Density	1.4±0.1 g/cm3	Boiling Point	522.8±60.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₄N₄O₄S	Melting Point	190-194ºC
	MSDS	Chinese USA	Flash Point	270.0±32.9 °C
	Symbol	GHS07	Signal Word	Warning

Use of Sulfadoxine

Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections.Target: AntiparasiticSulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide. Sulfadoxine is often used in combination with pyrimethamine to treat or prevent malaria. Both drugs are antifolates; they inhibit the production of enzymes involved in the synthesis of folic acid within the parasites. Either drug by itself is only moderately effective in treating malaria, because the parasite Plasmodium falciparum may be able to use exogenous folic acid, i.e. folic acid which is present in the parasite's environment, while in combination, the two substances have a synergistic effect which outbalances that ability [1, 2].

Name	sulfadoxine
Synonym	More Synonyms

Description	Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections.Target: AntiparasiticSulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide. Sulfadoxine is often used in combination with pyrimethamine to treat or prevent malaria. Both drugs are antifolates; they inhibit the production of enzymes involved in the synthesis of folic acid within the parasites. Either drug by itself is only moderately effective in treating malaria, because the parasite Plasmodium falciparum may be able to use exogenous folic acid, i.e. folic acid which is present in the parasite's environment, while in combination, the two substances have a synergistic effect which outbalances that ability [1, 2].
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
References	[1]. http://www.malaria-ipca.com/sulphadoxine_pyrimethamine.html [2]. http://en.wikipedia.org/wiki/Sulfadoxine/pyrimethamine

Description

Related Catalog

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

References

[1]. http://www.malaria-ipca.com/sulphadoxine_pyrimethamine.html

[2]. http://en.wikipedia.org/wiki/Sulfadoxine/pyrimethamine

Density	1.4±0.1 g/cm3
Boiling Point	522.8±60.0 °C at 760 mmHg
Melting Point	190-194ºC
Molecular Formula	C₁₂H₁₄N₄O₄S
Molecular Weight	310.329
Flash Point	270.0±32.9 °C
Exact Mass	310.073578
PSA	124.81000
LogP	0.34
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.623
Water Solubility	Soluble in ethanol & ammonium hydroxide (9:1) at 20mg/ml

Sulfadoxine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA9500000

CHEMICAL NAME :: Benzenesulfonamide, 4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)-

CAS REGISTRY NUMBER :: 2447-57-6

BEILSTEIN REFERENCE NO. :: 0625453

LAST UPDATED :: 199703

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C12-H14-N4-O4-S

MOLECULAR WEIGHT :: 310.36

WISWESSER LINE NOTATION :: T6N CNJ DO1 EO1 FMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,37,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 44 gm/kg/15D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 18 gm/kg/26W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Related to Chronic Data - death

REFERENCE :: CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26
RIDADR	NONH for all modes of transport
RTECS	DA9500000
HS Code	2935009090

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Sulfadoxine
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Sulfadoxine
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China
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China
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China
Product Name: Sulfadoxine
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Sulfadoxine

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