71142-71-7

71142-71-7 structure

Name: H-D-Phe-Pro-Arg-chloromethylketone trifluoroacetate salt
Chemical Name: H-D-Phe-Pro-Arg-chloromethylketone
CAS Number: 71142-71-7
Molecular Formula: C₂₁H₃₁ClN₆O₃
Molecular Weight: 450.96
Catalog: Biochemical Amino acids and their derivatives Arginine derivatives
Create Date: 2018-11-25 00:28:51
Modify Date: 2025-09-06 11:05:19
PPACK is a plasminogen activator (rt-PA) inhibitor. PPACK can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK also inhibits the binding of rt-PA to plasma protease inhibitors[1].

Name	H-D-Phe-Pro-Arg-chloromethylketone
Synonyms	H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE TRIFLUOROACETATE SALT phenylalanyl-prolyl-argininemethylchloride H-D-PHE-PRO-ARG-CMK TFA

Description	PPACK is a plasminogen activator (rt-PA) inhibitor. PPACK can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK also inhibits the binding of rt-PA to plasma protease inhibitors[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> PAI-1 Research Areas >> Cardiovascular Disease
References	[1]. Mohler MA, et, al. D-Phe-Pro-Arg-chloromethylketone: its potential use in inhibiting the formation of in vitro artifacts in blood collected during tissue-type plasminogen activator thrombolytic therapy. Thromb Haemost. 1986 Oct 21;56(2):160-4.