156251-01-3

156251-01-3 structure

Name	Melan-A, MART 1 (26-35),EAAGIGILTV
Synonyms	Melan-A,MART 1 (26-35) ANTIGEN SK29-AA (26-35) (HUMAN) L-α-Glutamyl-L-alanyl-L-alanylglycyl-L-isoleucylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-valine MART-1 (26-35) (HUMAN) GLU-ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL ANTIGEN LB39-AA (26-35) (HUMAN) MELAN-A PROTEIN (26-35) (HUMAN) EAAGIGILTV L-Valine, L-α-glutamyl-L-alanyl-L-alanylglycyl-L-isoleucylglycyl-L-isoleucyl-L-leucyl-L-threonyl- MART-1 (26-35),human (3) MELAN-A MART 1 (26-35)

Description	MART-1 (26-35) is amino acid residue 26 to 35 of MART-1 protein.
Related Catalog	Signaling Pathways >> Others >> Others Peptides Research Areas >> Inflammation/Immunology
In Vitro	MART-1 (Melan-A) gene is 18 kb long and comprises five exons. It is expressed in most melanoma tumor samples, and among normal cells, only in melanocytes[1]. In cancer immunotherapy, epitopes and variants derived from the MART-1/Melan-A protein are widely used as clinical vaccines. The epitopes spanning amino acid residues 26–35 and 27–35 from the MART-1/Melan-A protein, highly expressed in melanoma cells, provide a prime example of T cell recognition of multiple peptides and the use of peptide variants designed to elicit altered immunological responses[2].
References	[1]. Coulie PG, et al. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J Exp Med. 1994 Jul 1;180(1):35-42. [2]. Borbulevych OY, et al. Structures of MART-126/27-35 Peptide/HLA-A2 complexes reveal a remarkable disconnect between antigen structural homology and T cell recognition. J Mol Biol. 2007 Oct 5;372(5):1123-36.