59-32-5
59-32-5 structure
- Name: Chloropyramine
- Chemical Name: N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine
- CAS Number: 59-32-5
- Molecular Formula: C16H20ClN3
- Molecular Weight: 289.80300
- Catalog: API Antiallergic Antihistamine
- Create Date: 2018-04-14 08:00:00
- Modify Date: 2024-01-14 19:01:32
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Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma[1][2].
| Name | N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine |
|---|---|
| Synonyms |
Chlorneoantergan
Avapena Halopyramine Anaphylline Suprastin Synpen N-[(4-chlorophenyl)methyl]-N-[2-(dimethylamino)ethyl]pyridin-2-amine Synopen N-(4-Chlor-benzyl)-N',N'-dimethyl-N-<2>pyridyl-ethylendiamin N-[(4-chlorophenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine Chloropyramine Chlorpyraminum N-(4-Chlor-benzyl)-N',N'-dimethyl-N-[2]pyridyl-aethylendiamin Chlorpyramine N-(4-chloro-benzyl)-N',N'-dimethyl-N-[2]pyridyl-ethylenediamine EINECS 200-421-1 |
| Description | Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma[1][2]. |
|---|---|
| Related Catalog | |
| Target |
H1 Receptor |
| In Vitro | Chloropyramine (25, 50 μM; 24 h, 48 h) induces SASH1 expression and apoptosis in breast cancer cell lines[1]. Western Blot Analysis[1] Cell Line: Breast cancer cell lines Concentration: 25 or 50 μM Incubation Time: 24 h Result: Increased SASH1 expression in breast cancer cell lines. Apoptosis Analysis[1] Cell Line: T47D, MDA-MB-231 and BT-54 cells Concentration: 50 μM Incubation Time: 48 h Result: Induced apoptosis in breast cancer cell lines. |
| In Vivo | Chloropyramine (i.p.; 10 mg/kg) abolishes hypothermia in rats[2]. Animal Model: Rats[2] Dosage: 10 mg/kg Administration: Intraperitoneal Result: Reduced histamine-induced hypothermia. |
| Density | 1.158g/cm3 |
|---|---|
| Boiling Point | 413.5ºC at 760 mmHg |
| Melting Point | 25°C |
| Molecular Formula | C16H20ClN3 |
| Molecular Weight | 289.80300 |
| Flash Point | 203.9ºC |
| Exact Mass | 289.13500 |
| PSA | 19.37000 |
| LogP | 3.30320 |
| Index of Refraction | 1.6 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Hazard Codes | Xi |
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59-32-5 |
| Literature: DE931828 , ; DRP/DRBP Org.Chem. |
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| Literature: DE931828 , ; DRP/DRBP Org.Chem. |
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| Literature: US2607778 , ; |
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| Literature: Acta Chimica Academiae Scientiarum Hungaricae, , vol. 15, p. 265,269 |
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| Literature: Acta Chimica Academiae Scientiarum Hungaricae, , vol. 15, p. 265,269 |
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59-32-5 |
| Literature: Acta Chimica Academiae Scientiarum Hungaricae, , vol. 15, p. 265,269 |
