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Product Name: Diethyl maleate
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China
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Dayang Chem (Hangzhou) Co., Ltd.
China
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141-05-9

141-05-9 structure

Name: diethylmaleate
Chemical Name: diethyl maleate
CAS Number: 141-05-9
Molecular Formula: C₈H₁₂O₄
Molecular Weight: 172.178
Catalog: Chemical pesticide Insecticide intermediate
Create Date: 2018-10-04 06:42:27
Modify Date: 2024-01-02 06:22:25
Diethyl maleate is a maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. Diethyl maleate (DEM), a thiol-reactive α,β-unsaturated carbonyl compound, depletes glutathione (GSH) in exposed cells[1].

Name	diethyl maleate
Synonyms	cis-Diethyl maleate MFCD00009191 diethyl L-malic ester Diethyl L-(-)-Malate (S)-(-)-Aepfelsaeure-diethylester cis-Propenoic acid diethyl ester Maleic acid, diethyl ester EINECS 205-451-9 (S)-malic acid diethyl ester diethylmaleate 2-Butenedioic acid, diethyl ester, (2Z)- Diethyl (2Z)-2-butenedioate Diethyl (2Z)-but-2-enedioate cis-EtO2CCH=CHCO2Et L-(-)-Malic Acid Diethyl Ester (S)-(-)-diethyl 2-hydroxybutandioate diethyl (Z)-but-2-enedioate diethyl (2Z)but-2-ene-1,4-dioate 1,4-diethyl (2Z)-but-2-enedioate 2-Butenedioic acid (2Z)-, diethyl ester 2-Butenedioic acid (Z)-, diethyl ester maleic acid diethyl ester Ethyl Maleate (2S)-2-hydroxybutanedioic acid diethylester Diethyl maleate diethyl (S)-malate (Z)-2-Butenedioic acid diethyl ester Irsogladine Impurity 3

Description	Diethyl maleate is a maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. Diethyl maleate (DEM), a thiol-reactive α,β-unsaturated carbonyl compound, depletes glutathione (GSH) in exposed cells[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Andrea Gille, et al. Nuclear trapping of inactive FOXO1 by the Nrf2 activator diethyl maleate. Redox Biol. 2019 Jan;20:19-27.

Density	1.1±0.1 g/cm3
Boiling Point	214.0±0.0 °C at 760 mmHg
Melting Point	−10 °C(lit.)
Molecular Formula	C₈H₁₂O₄
Molecular Weight	172.178
Flash Point	93.3±0.0 °C
Exact Mass	172.073563
PSA	52.60000
LogP	1.68
Vapour density	5.93 (vs air)
Vapour Pressure	0.2±0.4 mmHg at 25°C
Index of Refraction	1.443
Stability	Stable. Combustible. Incompatible with oxidizing agents, bases, acids, reducing agents.
Water Solubility	insoluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ON1225000

CHEMICAL NAME :: Maleic acid, diethyl ester

CAS REGISTRY NUMBER :: 141-05-9

BEILSTEIN REFERENCE NO. :: 1100825

LAST UPDATED :: 199806

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C8-H12-O4

MOLECULAR WEIGHT :: 172.20

WISWESSER LINE NOTATION :: 2OV1U1VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3070 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 8700 nmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 182,135,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317-H319-H412
Precautionary Statements	P273-P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant;
Risk Phrases	R43
Safety Phrases	S26-S36/37-S37-S24
RIDADR	3334
WGK Germany	2
RTECS	ON1225000
HS Code	29171990

Precursor 9
108-31-6 64-17-5 762-42-5 623-73-4
292638-84-7 98-83-9 73331-49-4 608-82-2
872-05-9
DownStream 10
710-43-0 3999-55-1 3588-17-8 4753-29-1
33422-35-4 923-42-2 110-15-6 924-44-7
188944-76-5 192389-48-3

HS Code	2917190090
Summary	2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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