diethylmaleate

Modify Date: 2025-08-22 11:22:46

diethylmaleate structure	Common Name	diethylmaleate
	CAS Number	141-05-9	Molecular Weight	172.178
	Density	1.1±0.1 g/cm3	Boiling Point	214.0±0.0 °C at 760 mmHg
	Molecular Formula	C₈H₁₂O₄	Melting Point	−10 °C(lit.)
	MSDS	Chinese USA	Flash Point	93.3±0.0 °C
	Symbol	GHS07	Signal Word	Warning

Use of diethylmaleate

Diethyl maleate is a maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. Diethyl maleate (DEM), a thiol-reactive α,β-unsaturated carbonyl compound, depletes glutathione (GSH) in exposed cells[1].

Name	diethyl maleate
Synonym	More Synonyms

Description	Diethyl maleate is a maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. Diethyl maleate (DEM), a thiol-reactive α,β-unsaturated carbonyl compound, depletes glutathione (GSH) in exposed cells[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Andrea Gille, et al. Nuclear trapping of inactive FOXO1 by the Nrf2 activator diethyl maleate. Redox Biol. 2019 Jan;20:19-27.

Density	1.1±0.1 g/cm3
Boiling Point	214.0±0.0 °C at 760 mmHg
Melting Point	−10 °C(lit.)
Molecular Formula	C₈H₁₂O₄
Molecular Weight	172.178
Flash Point	93.3±0.0 °C
Exact Mass	172.073563
PSA	52.60000
LogP	1.68
Vapour density	5.93 (vs air)
Vapour Pressure	0.2±0.4 mmHg at 25°C
Index of Refraction	1.443
Stability	Stable. Combustible. Incompatible with oxidizing agents, bases, acids, reducing agents.
Water Solubility	insoluble

diethylmaleate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ON1225000

CHEMICAL NAME :: Maleic acid, diethyl ester

CAS REGISTRY NUMBER :: 141-05-9

BEILSTEIN REFERENCE NO. :: 1100825

LAST UPDATED :: 199806

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C8-H12-O4

MOLECULAR WEIGHT :: 172.20

WISWESSER LINE NOTATION :: 2OV1U1VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3070 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 8700 nmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 182,135,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317-H319-H412
Precautionary Statements	P273-P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant;
Risk Phrases	R43
Safety Phrases	S26-S36/37-S37-S24
RIDADR	3334
WGK Germany	2
RTECS	ON1225000
HS Code	29171990

Precursor 9
CAS#:108-31-6 Maleic anhydride CAS#:64-17-5 Ethanol CAS#:762-42-5 Dimethyl but-2-... CAS#:623-73-4 EDA
CAS#:292638-84-7 phenylene-ethylene CAS#:98-83-9 α-methylstyrene CAS#:73331-49-4 [o-((trimethyls... CAS#:608-82-2 diethyl 2,3-dib...
CAS#:872-05-9 1-decene
DownStream 10
CAS#:710-43-0 CIS-DIETHYL CYC... CAS#:3999-55-1 (E)-1,2-Cyclopr... CAS#:3588-17-8 trans,trans-Muc... CAS#:4753-29-1 diethyl 2-(1-ni...
CAS#:33422-35-4 Ethyl (3-oxo-2-... CAS#:923-42-2 1,2,4-Butanetri... CAS#:110-15-6 Succinic acid CAS#:924-44-7 Ethyl glyoxylate
CAS#:188944-76-5 diethyl 2-bromo... CAS#:192389-48-3 diethyl (2S)-2-...

HS Code	2917190090
Summary	2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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The Colorado potato beetle (Leptinotarsa decemlineata (Say)) in the north Xinjiang Uygur autonomous region has evolved resistance to various types of insecticides. Chlorantraniliprole is a novel anthr...

Phenobarbital induction and chemical synergism demonstrate the role of UDP-glucuronosyltransferases in detoxification of naphthalophos by Haemonchus contortus larvae.

Antimicrob. Agents Chemother. 58(12) , 7475-83, (2014)

We used an enzyme induction approach to study the role of detoxification enzymes in the interaction of the anthelmintic compound naphthalophos with Haemonchus contortus larvae. Larvae were treated wit...

Designing greener plasticizers: Effects of alkyl chain length and branching on the biodegradation of maleate based plasticizers.

Chemosphere 134 , 106-12, (2015)

The ubiquitous presence of the plasticizer di (2-ethylhexyl) phthalate (DEHP) in the environment is of concern due to negative biological effects associated with it and its metabolites. In particular,...

cis-Diethyl maleate

MFCD00009191

diethyl L-malic ester

Diethyl L-(-)-Malate

(S)-(-)-Aepfelsaeure-diethylester

cis-Propenoic acid diethyl ester

Maleic acid, diethyl ester

EINECS 205-451-9

(S)-malic acid diethyl ester

diethylmaleate

2-Butenedioic acid, diethyl ester, (2Z)-

Diethyl (2Z)-2-butenedioate

Diethyl (2Z)-but-2-enedioate

cis-EtO2CCH=CHCO2Et

L-(-)-Malic Acid Diethyl Ester

(S)-(-)-diethyl 2-hydroxybutandioate

diethyl (Z)-but-2-enedioate

diethyl (2Z)but-2-ene-1,4-dioate

1,4-diethyl (2Z)-but-2-enedioate

2-Butenedioic acid (2Z)-, diethyl ester

2-Butenedioic acid (Z)-, diethyl ester

maleic acid diethyl ester

Ethyl Maleate

(2S)-2-hydroxybutanedioic acid diethylester

Diethyl maleate

diethyl (S)-malate

(Z)-2-Butenedioic acid diethyl ester

Irsogladine Impurity 3

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China
Product Name: Diethyl maleate
Price: ￥Inquiry/1g
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Diethyl maleate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
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diethylmaleate

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diethylmaleate Biological Activity

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