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341028-37-3

341028-37-3 structure
341028-37-3 structure
  • Name: Alagebrium chloride
  • Chemical Name: 2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenylethanone,chloride
  • CAS Number: 341028-37-3
  • Molecular Formula: C13H14ClNOS
  • Molecular Weight: 267.77400
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2018-10-07 10:44:23
  • Modify Date: 2024-01-10 12:12:17
  • Alagebrium chloride is an advanced glycation end product (AGE) inhibitor.
Name 2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenylethanone,chloride
Synonyms Alagebrium chloride (USAN)
UNII-79QS8K2877
Alagebrium chloride
ALT-711
4,5-Dimethyl-3-(2-oxo-2-phenylethyl)thiazol-3-ium chloride
2-(4,5-dimethyl-1,3-thiazol-3-yl)-1-phenyl-ethanone chloride
Description Alagebrium chloride is an advanced glycation end product (AGE) inhibitor.
Related Catalog
Target

AGE[1]
In Vitro Alagebrium chloride is an advanced glycation end product (AGE) inhibitor. Endothelial cell (EC) proliferation is increased for all groups receiving Alagebrium (ALT-711), particularly when seeded on matrix from the AAo of obese (ZO) and diabetic (ZD) rats[2].
In Vivo Blood pressure is not affected by treatment with Alagebrium. In diabetic RAGE apoE double-KO mice, treatment with Alagebrium is associated with a modest reduction in renal mass and reduces hyperfiltration compare with nontreated mice. Treatment with Alagebrium in diabetic RAGE apoE double-KO mice is associated with a further reduction in glomerular collagen IV levels, approaching levels observed in control mice[1]. Body weight, heart rate (HR), and mean blood pressure (BP) are similar in Zucker lean (ZL), obese (ZO), and diabetic (ZD) groups in the absence or presence of Alagebrium (ALT-711). Alagebrium increases blood flow (BF) in ZO rats but reduces distal vascular resistance in ZD rats. A decrease in neointimal hyperplasia (NH) intrastrut thickness as a function of local radius is found in all groups with Alagebrium treatment. A significant increase in TGF-β expression is also found in the AAo of ZL rats treated with Alagebrium[2].
Cell Assay Human aortic endothelial cells (HAECs) are seeded on decellularized matrices derived from the abdominal aorta (AAo) of Zucker lean (ZL), obese (ZO), and diabetic (ZD) rats with or without Alagebrium (ALT-711) (20 μg/mL in Dulbecco's PBS with 1× antibiotic-antimycotic). Experiments are performed when cells reach 80 to 90% confluence. Flow chambers are sealed to the HAEC monolayers via a vacuum network. Flow is driven by a Masterflex L/S peristaltic pump in a humidified chamber heated to 37°C for 4 h. Leibovitz-15 medium, supplemented with 10% FBS, endothelial BulletKit, and 1× antibiotic-antimycotic solution, is used as the flow medium to maintain pH in the absence of CO2[2].
Animal Admin RAGE apoE mice are randomized to be treated with Alagebrium (1 mg/kg/day by gavage), or no treatment (n=20/group). After 20 weeks of diabetes, mice are placed into individual metabolic cages for 24 h and urine is collected. Body weight as well as fluid and food intake are recorded. Urinary albumin excretion is estimated in urine samples by a mouse albumin enzyme-linked immunosorbent assay (ELISA) kit according to the kit protocol. Urinary and serum creatinine concentrations are measured by high-performance liquid chromatography (HPLC). Systolic blood pressure is assessed by a noninvasive tail cuff method in conscious mice at the end of the study[1].
References

[1]. Watson AM, et al. Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGEactivation in diabetic apolipoprotein E knockout mice. Diabetes. 2012 Aug;61(8):2105-13.

[2]. Wang H, et al. Alagebrium inhibits neointimal hyperplasia and restores distributions of wall shear stress by reducing downstream vascular resistance in obese and diabetic rats. Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1130-40.
Molecular Formula C13H14ClNOS
Molecular Weight 267.77400
Exact Mass 267.04800
PSA 49.19000
Hazard Codes Xi
HS Code 2934100090
HS Code 2934100090
Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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