Top Suppliers:I want be here
Related CAS#:
6061-96-7 117041-96-0
64815-78-7 88684-13-3
54889-76-8 2998-18-7
7251-90-3 505-36-2
18886-16-3 600-07-7

6061-96-7

6061-96-7 structure
6061-96-7 structure
  • Name: 2-Methylcitric acid
  • Chemical Name: 2-methylcitric acid
  • CAS Number: 6061-96-7
  • Molecular Formula: C7H10O7
  • Molecular Weight: 206.15000
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2018-03-21 08:00:00
  • Modify Date: 2024-01-04 11:30:13
  • 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].
Name 2-methylcitric acid
Synonyms 2-hydroxy-butane-1,2,3-tricarboxylic acid
1,2,3-Butanetricarboxylic acid,2-hydroxy
2-Hydroxy-butan-1,2,3-tricarbonsaeure
2-hydroxybutane-1,2,3-tricarboxylate
2-methylcitrate
2-hydroxy-1,2,3-butantricarbons
Methylcitronensaeure
2-hydroxybutane-1,2,3-tricarboxylic acid
2-hydroxy-1,2,3-butanetricarboxylic acid
2-Methylcitric acid
Description 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].
Related Catalog
Target

Human Endogenous Metabolite
In Vitro 2-Methylcitric acid (Methylcitric acid) impairs glutamate metabolism and induces permeability transition in brain mitochondria. 2-Methylcitric acid inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM[1]. 2-Methylcitric acid (1-3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca2+-loaded mitochondria supported by different substrates[1]. 2-Methylcitric acid behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis. 2-Methylcitric acid does not significantly impair mitochondrial glutamate transport. 2-Methylcitric acid does not significantly impair glutamate mitochondrial transport in liver mitochondria[1].
References

[1]. Palacios S, et al. Propionyl Coenzyme A Is a Common Intermediate in the 1,2-Propanediol and Propionate Catabolic Pathways Needed for Expression of the prpBCDE Operon during Growth of Salmonella enterica on 1,2-Propanediol. J Bacteriol. 2003 May;185(9):2802-10.
Density 1.178g/cm3
Boiling Point 464.4ºC at 760 mmHg
Melting Point 79°C (lit.)
Molecular Formula C7H10O7
Molecular Weight 206.15000
Flash Point 234.7ºC
Exact Mass 206.04300
PSA 132.13000
Index of Refraction 1.586
HS Code 2918199090
859179-78-5 structure

859179-78-5

~%

6061-96-7 structure

6061-96-7
Literature: Habicht; Schneeberger Helvetica Chimica Acta, 1956 , vol. 39, p. 1316,1318
Precursor  1

DownStream  0

HS Code 2918199090
Summary 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Chemsrc provides CAS#:6061-96-7 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 6061-96-7 | Chemsrc address: https://m.chemsrc.com/en/baike/829956.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved