191421-10-0

191421-10-0 structure

Name: 5-NIdR
Chemical Name: 1-(β-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE
CAS Number: 191421-10-0
Molecular Formula: C₁₃H₁₄N₂O₅
Molecular Weight: 278.26100
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-08-06 22:31:23
Modify Date: 2024-01-17 06:53:12
5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole), an artificial nucleoside, exhibits the ability to inhibit the replication of DNA lesions generated by Temozolomide (HY-17364). 5-NIdR induces cancer cells apoptosis and arrests cell cycle at G0 phase. 5-NIdR enhances Temozolomide anti-tumor efficacy in murine glioblastoma model[1].

Name	1-(β-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE

Description	5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole), an artificial nucleoside, exhibits the ability to inhibit the replication of DNA lesions generated by Temozolomide (HY-17364). 5-NIdR induces cancer cells apoptosis and arrests cell cycle at G0 phase. 5-NIdR enhances Temozolomide anti-tumor efficacy in murine glioblastoma model[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	5-NIdR (12.5-100 μM；24-72 小时) 以剂量依赖性方式抑制人胶质母细胞瘤细胞系（U87、A172 和 SW1088）的生长[1]。 5-NIdR (1-100 μg/mL；72 h) 在 U87 细胞中诱导细胞凋亡，并以 100 μg/mL 的浓度过夜孵育，使细胞周期停滞在 G0 期[1]。
In Vivo	5-NIdR (100 mg/kg；腹腔注射；连续 5 天) 与替莫唑胺 (40 mg/kg) 联用，在胶质母细胞瘤小鼠异种移植模型中导致肿瘤完全消退。而 Temozolomide 单独使用，只能延迟肿瘤的生长[1]。
References	[1]. Choi JS, et al. Inhibition of Translesion DNA Synthesis as a Novel Therapeutic Strategy to Treat Brain Cancer. Cancer Res. 2018 Feb 15;78(4):1083-1096.