Name | Disodium Clodronate Tetrahydrate |
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Synonyms |
Sodium (dichloromethylene)bis[hydrogen (phosphonate)] hydrate (2:1:4)
Phosphonic acid, (dichloromethylene)bis-, sodium salt, hydrate (1:2:4) Disodium clodronate tetrahydrate clodronate disodium tetrahydrate Clodronate Disodium |
Description | Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain[1][2]. |
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Related Catalog | |
Target |
vesicular ATP release[1] |
In Vitro | Clodronate disodium tetrahydrate, a first-generation bisphosphonate, significantly attenuates neuropathic and inflammatory pain unrelated to bone abnormalities via inhibition of VNUT, a key molecule for the initiation of purinergic chemical transmission [1]. Clodronate disodium tetrahydrate is an allosteric modulator of VNUT Cl- dependence [1]. Clodronate disodium tetrahydrate acts as antiresorptive in osteoporosis[2]. |
In Vivo | Clodronate disodium tetrahydrate (10 mg/kg; i.v.) attenuates inflammatory pain via VNUT inhibition[1]. Clodronate disodium tetrahydrate attenuates inflammation via VNUT inhibition [1]. Animal Model: C57BL/6 mice (22-30 g)[1] Dosage: 10 mg/kg Administration: Intravenous injection Result: Attenuated carrageenan- or complete Freund’s adjuvant (CFA)-evoked inflammatory pain. |
References |
Molecular Formula | CH12Cl2Na2O10P2 |
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Molecular Weight | 360.917 |
Exact Mass | 359.892151 |
PSA | 177.26000 |
LogP | 1.04990 |