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50-22-6

50-22-6 structure

50-22-6 structure

Name: Corticosterone
Chemical Name: corticosterone
CAS Number: 50-22-6
Molecular Formula: C₂₁H₃₀O₄
Molecular Weight: 346.461
Catalog: API Antibiotics Other antibiotics
Create Date: 2018-02-09 08:00:00
Modify Date: 2026-06-30 11:27:12
Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

Name	corticosterone
Synonyms	11β,21-Dihydroxyprogesterone Corticosterone- -d4 compoundb DELTA4-PREGNEN-11BETA, 21-DIOL-3, 20-DIONE EINECS 200-019-6 Pregn-4-ene-3,20-dione, 11beta,21-dihydroxy Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11-β)- (9CI) Corticosterone - - Calbiochem 11BETA,21-DIHYDROXY-PROGESTERONE 11β,21-Dihydroxy-4-pregnene-3,20-dione 4-Pregnen-11,21-diol-3,20-dione-d8 11BETA,21-DIHYDROXY-4-PRENENE-3,20-DIONE KENDALL'S 'B' CORTICOSTERONE //BP 4-PREGNEN-11-BETA, 21-DIOL-3,20-DIONE Corticosterone solution Compound B 11,21-Dihydroxypregn-4-ene-3,20-dione 11,12-dihydroxyprogesterone 4-Pregnene-11b,21-diol-3,20-dione 11b,21-Dihydroxy-4-pregnene-3,20-dione 11b,21-Dihydroxyprogesterone CORTICOSTERONE CRYSTALLINE REICHSTEIN'S SUBSTANCE ''H'' 11b,21-Dihydroxypregn-4-ene-3,20-dione CORTICOSTERONE(RG) (8R,9S,10S,11R,13S,14R,17R)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one corticosterone solution,100ppm KENDALL'S COMPOUND 'B' Corticosterone,11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H Corticosteron 4-PREGNEN-11B,21-DIOL-3,20-DIONE 11-Hydroxycorticoaldosterone Corticosterone Corticosterone (8S,9S,10R,11S,13S,14S,17S)-17-glycoloyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one MFCD00037715 Reichstein's B (11b)-11,21-Dihydroxypregn-4-ene-3,20-dione (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one NSC-9705 17-Deoxycortisol 4-PREGNENE-11BETA,21-DIOL-3,20-DIONE Corticisterone Corticosteroid Raw Powder 11BETA,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE CORTICOSTERONE VETRANAL 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendalls Compound B, Reichsteins Substance H 11-beta,21-Dihydroxypregn-3,20-dione CORTICOSTERONE KENDALL'S COMPOUND B 11-beta,21-dihydroxy-pregn-4-ene-20-dione Corticosterone> 21-dihydroxy-20-dion(11-beta)-pregn-4-ene-11 KENDALL'S COMPOUND ''B'' Azlocilline (11BETA)-11,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione 21-Dihydroxyprogesterone (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one 11BETA,21-DIHYDROXY-4-PREGNENE-3,20-DIONE 4-08-00-02907 (Beilstein Handbook Reference) Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta) REICHSTEIN'S SUBSTANCE 'H' 4-Pregnene-11β,21-diol-3,20-dione Pregn-4-ene-3,20-dione,11,21-dihydroxy-, (11b) 11,21-Dihydroxyprogesterone REICHSTEIN'S SUBSTANCE H

Description	Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Neurological Disease Natural Products >> Steroids
Target	Human Endogenous Metabolite
References	[1]. Gasser PJ, et al. Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organiccation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. J Neurosci. 2006 Aug 23;26(34):8758-8766.

Density	1.2±0.1 g/cm3
Boiling Point	529.2±50.0 °C at 760 mmHg
Melting Point	179-183 °C(lit.)
Molecular Formula	C₂₁H₃₀O₄
Molecular Weight	346.461
Flash Point	288.0±26.6 °C
Exact Mass	346.214417
PSA	74.60000
LogP	1.76
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.576
Storage condition	Store at RT
Stability	Stable, but light sensitive. Incompatible with strong oxidizing agents.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GM7650000

CHEMICAL NAME :: Corticosterone

CAS REGISTRY NUMBER :: 50-22-6

BEILSTEIN REFERENCE NO. :: 2339601

LAST UPDATED :: 199703

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C21-H30-O4

MOLECULAR WEIGHT :: 346.51

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 CQ E1 FV1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 14 mg/kg

SEX/DURATION :: female 19-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - respiratory system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 525 mg/kg

SEX/DURATION :: female 12-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - endocrine system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 500 mg/kg

SEX/DURATION :: female 8-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 84 mg/kg

SEX/DURATION :: female 16-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1472 mg/kg

SEX/DURATION :: female 11-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 400 mg/kg

SEX/DURATION :: female 11-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 100 mg/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 400 mg/kg

SEX/DURATION :: female 11-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 40 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 80 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Bird - chicken Embryo

DOSE/DURATION :: 1500 pmol/L

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 257,804,1975

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xi,N,Xn,T
Risk Phrases	R43
Safety Phrases	S36
RIDADR	2811.0
WGK Germany	3
RTECS	GM7650000
Hazard Class	6.1

Precursor 10
50-23-7 117888-43-4 64-85-7 600-67-9
39833-13-1 1173-26-8 58761-73-2 111611-71-3
74428-34-5 76183-58-9
DownStream 6
516-15-4 298-25-9 600-57-7 1173-26-8
13479-38-4 96913-12-1

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