141396-28-3
141396-28-3 structure
- Name: Argatroban
- Chemical Name: Argatroban Monohydrate
- CAS Number: 141396-28-3
- Molecular Formula: C23H38N6O6S
- Molecular Weight: 526.65
- Catalog: API Blood system medication Anticoagulant and antiplatelet drugs
- Create Date: 2018-07-21 12:12:11
- Modify Date: 2026-07-01 20:14:53
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Argatroban monohydrate is a direct, selective thrombin inhibitor.Target: ThrombinArgatroban may have a complementary effect for preventing thrombus formation without aggravating bleeding tendency because of its monotarget specificity to thrombin. Administration (0.5 to 2 micrograms/kg/min) of argatroban is a safe anticoagulant for left heart bypass in repairs of traumatic aortic rupture associated with multiple organ injuries [1]. Argatroban, as compared with heparin, appears to enhance reperfusion with TPA in patients with AMI, particularly in those patients with delayed presentation. The incidences of major bleeding and adverse clinical outcome were lower in the patients receiving argatroban [2].
| Name | Argatroban Monohydrate |
|---|---|
| Synonyms |
US-DMF：
gatroban (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecboxylic acid (2r,4r)-1-((2s)-5-((aminoiminomethyl)amino)-1-oxo-2-(((1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl)amino)pentyl)-4-methyl-2-piperidinecboxylic acid (2R,4R)-1-((2S)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-cboxylic acid hydrate GN1600 (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-cboxylic acid gatroban Monohydrate, 10 mM in DMSO (2R,4R)-4-Methyl-1-[Nalpha-[(3-methyl-1,2,3,4-tetrahydro-8-q (2R,4R)-1-{N-(Diaminomethylene)-N-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-ornithyl}-4-methyl-2-piperidinecarboxylic acid gatroban monohydrate, Thrombin inhibitor Agatroban monohydrate (2r,4r)-4-methyl-1-[n-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-l-ginyl]-2-piperidinecboxylic acid (2R,4R)-1-{N-(diaminomethylidene)-N-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl]-L-ornithyl}-4-methylpiperidine-2-carboxylic acid (2R,4R)-1-[N-(methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-ginyl]-4-methyl-2-piperidinecboxylic acid monohydrate (2R,4R)-4-Methyl-1-{N-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl}-2-piperidinecarboxylic acid hydrate (1:1) Argatroban monohydrate gatroban Monohydrate> gatroban gatroban hydrate (MD805 Argatroban anhydrous UNII:IY90U61Z3S Benzenesulfonicacid,8-(acetylamino)-,hydrazide (2R,4R)-1-((2S)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-cboxylic acid hydrate gatroban Impurity) (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecboxylic acid hydrate gatroban (hydrate) (2R,4R)-4-Methyl-1-[Nalpha-[(3-Methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-ginyl]-2-piperidinecboxylic acid (2r,4r)-1-[(2s)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecboxylic acid gipidine monohydrate GIPIDINE MONOHYDRATE; ACOVA MONOHYDRATE 2-Piperidinecarboxylic acid, 1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-, (2R,4R)-, hydrate (1:1) Argatroban (monohydrate) API Cas:141-3 gatroban Monohydrate (2R,4R)-4-Methyl-1-{N-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl]-L-arginyl}piperidine-2-carboxylic acid MFCD00895735 Acova monohydrate (2R,4R)-4-Methyl-1-[N2-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-2-piperidinecarboxylic Acid gatroban 1-hydrate gatroban API AG, SAJ UNII:OCY3U280Y3 |
| Description | Argatroban monohydrate is a direct, selective thrombin inhibitor.Target: ThrombinArgatroban may have a complementary effect for preventing thrombus formation without aggravating bleeding tendency because of its monotarget specificity to thrombin. Administration (0.5 to 2 micrograms/kg/min) of argatroban is a safe anticoagulant for left heart bypass in repairs of traumatic aortic rupture associated with multiple organ injuries [1]. Argatroban, as compared with heparin, appears to enhance reperfusion with TPA in patients with AMI, particularly in those patients with delayed presentation. The incidences of major bleeding and adverse clinical outcome were lower in the patients receiving argatroban [2]. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 801.3±75.0 °C at 760 mmHg |
| Melting Point | -41.5 °C |
| Molecular Formula | C23H38N6O6S |
| Molecular Weight | 526.65 |
| Flash Point | 438.4±37.1 °C |
| PSA | 195.32000 |
| LogP | 2.56 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.674 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Hazard Codes | Xi |
|---|---|
| Risk Phrases | R36:Irritating to the eyes. R10:Flammable. |
| Safety Phrases | S39-S26-S16 |
| RIDADR | NONH for all modes of transport |
| RTECS | TM6126610 |
| HS Code | 2935009090 |
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |