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58652-20-3

58652-20-3 structure
58652-20-3 structure
  • Name: Nomegestrol acetate
  • Chemical Name: Nomegestrol acetate
  • CAS Number: 58652-20-3
  • Molecular Formula: C23H30O4
  • Molecular Weight: 370.482
  • Catalog: API Hormone and endocrine-regulating drugs Estrogen and progestogen drugs
  • Create Date: 2018-03-25 08:00:00
  • Modify Date: 2025-08-25 11:28:00
  • Nomegestrol acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors[1].
Name Nomegestrol acetate
Synonyms [(8S,9S,10R,13S,14S,17R)-17-acetyl-6,13-dimethyl-3-oxo-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate
EINECS 261-379-8
6-Methyl-3,20-dioxo-19-norpregna-4,6-dien-17-yl acetate
Lutenyl
(17a)-17-Acetyl-6-methyl-3-oxoestra-4,6-dien-17-yl acetate
MFCD00941390
17-Acetoxy-6-methyl-19-norpregna-4,6-diene-3,20-dione
Nomegestrol acetate
Estra-4,6-dien-3-one, 17-acetyl-17-(acetyloxy)-6-methyl-, (17α)-
19-normegestrol acetate
Description Nomegestrol acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors[1].
Related Catalog
Target

Progesterone receptor[1]

References

[1]. Mueck AO, et al. Nomegestrol acetate, a novel progestogen for oral contraception. Steroids. 2011 May;76(6):531-9.
Density 1.2±0.1 g/cm3
Boiling Point 507.3±50.0 °C at 760 mmHg
Molecular Formula C23H30O4
Molecular Weight 370.482
Flash Point 219.8±30.2 °C
Exact Mass 370.214417
PSA 60.44000
LogP 3.34
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.554
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RC8899200
CHEMICAL NAME :
19-Norpregna-4,6-diene-3,20-dione, 17-alpha-hydroxy-6-methyl-, acetate
CAS REGISTRY NUMBER :
58652-20-3
LAST UPDATED :
199603
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C23-H30-O4
MOLECULAR WEIGHT :
370.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
1050 ug/kg/21D-I
TOXIC EFFECTS :
Endocrine - changes in luteinizing hormone Endocrine - estrogenic Endocrine - effect on menstrual cycle
REFERENCE :
BJOGAS British Journal of Obstetrics and Gynaecology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.82- 1975- Volume(issue)/page/year: 94,1199,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,657,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,657,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,657,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,657,1984 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
5 mg/kg
SEX/DURATION :
female 4 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,710,1983
Symbol GHS08 GHS09
GHS08, GHS09
Signal Word Warning
Hazard Statements H361fd-H400
Precautionary Statements P280
Hazard Codes N
Risk Phrases 63-50
Safety Phrases 61
RIDADR UN 3077 9 / PGIII
RTECS RC8899200
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