Nomegestrol acetate
Nomegestrol acetate structure
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Common Name | Nomegestrol acetate | ||
|---|---|---|---|---|
| CAS Number | 58652-20-3 | Molecular Weight | 370.482 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 507.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C23H30O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 219.8±30.2 °C | |
| Symbol |
GHS08, GHS09 |
Signal Word | Warning | |
Use of Nomegestrol acetateNomegestrol acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Nomegestrol acetate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Nomegestrol acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors[1]. |
|---|---|
| Related Catalog | |
| Target |
Progesterone receptor[1] |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 507.3±50.0 °C at 760 mmHg |
| Molecular Formula | C23H30O4 |
| Molecular Weight | 370.482 |
| Flash Point | 219.8±30.2 °C |
| Exact Mass | 370.214417 |
| PSA | 60.44000 |
| LogP | 3.34 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.554 |
| InChIKey | IIVBFTNIGYRNQY-YQLZSBIMSA-N |
| SMILES | CC(=O)OC1(C(C)=O)CCC2C3C=C(C)C4=CC(=O)CCC4C3CCC21C |
| Storage condition | 2-8°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS08, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H361fd-H400 |
| Precautionary Statements | P280 |
| Hazard Codes | N |
| Risk Phrases | 63-50 |
| Safety Phrases | 61 |
| RIDADR | UN 3077 9 / PGIII |
| RTECS | RC8899200 |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Changing convention in combination oral contraceptives: estradiol and nomegestrol acetate in a monophasic 24/4 regimen.
J. Fam. Plann. Reprod. Health Care 39(3) , 211-6, (2013) Initial oral contraceptive regimens were characterised by high doses of ethinylestradiol (EE) and a progestogen in a 21-day regimen that either included seven additional hormone-free tablets or simply... |
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A new contraceptive pill containing 17β-estradiol and nomegestrol acetate.
Womens. Health (Lond. Engl.) 9(1) , 13-23, (2013) Most combined oral contraceptive pills contain ethinyl estradiol (EE) with progestins. In order to minimize the pill's cardiovascular risks, the concept of using 17β-estradiol (E2), the endogenous est... |
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The “newer” progestogens and postmenopausal hormone therapy (HRT)
J. Steroid Biochem. Mol. Biol. 142 , 48-51, (2014) • The “newer” progestogens have a high bioavailability. • The “newer” progestogens have a sufficient progestogenic effect. • The “newer” progestogens do not cause undue side effects. • The “newer” pro... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
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Name: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint...
Source: Broad Institute
Target: N/A
External Id: 2084-01_Activator_SinglePoint_HTS_Activity
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Name: Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc...
Source: The Scripps Research Institute Molecular Screening Center
Target: N/A
External Id: GDH-TPI_INH_ABS_1536_1X%INH CSRUN
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805
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Name: Inhibition of cell viability relative to arbidol control (inhibition index > 1 indica...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303819
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Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| [(8S,9S,10R,13S,14S,17R)-17-acetyl-6,13-dimethyl-3-oxo-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate |
| EINECS 261-379-8 |
| 6-Methyl-3,20-dioxo-19-norpregna-4,6-dien-17-yl acetate |
| Lutenyl |
| (17a)-17-Acetyl-6-methyl-3-oxoestra-4,6-dien-17-yl acetate |
| MFCD00941390 |
| 17-Acetoxy-6-methyl-19-norpregna-4,6-diene-3,20-dione |
| Nomegestrol acetate |
| 19-normegestrol acetate |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the boiling point of Nomegestrol acetate? |
| A: Boiling point of Nomegestrol acetate is 507.3±50.0 °C at 760 mmHg. |
| Q: What is the molecular weight of Nomegestrol acetate? |
| A: Molecular weight of Nomegestrol acetate is 370.482. |
| Q: What is the English name of Nomegestrol acetate? |
| A: The English name of Nomegestrol acetate is Nomegestrol acetate. |
| Q: What are the storage conditions for Nomegestrol acetate? |
| A: Storage conditions for Nomegestrol acetate: 2-8°C. |
| Q: What is the SMILES notation of Nomegestrol acetate? |
| A: SMILES notation of Nomegestrol acetate is CC(=O)OC1(C(C)=O)CCC2C3C=C(C)C4=CC(=O)CCC4C3CCC21C. |
| Q: What is the LogP of Nomegestrol acetate? |
| A: LogP of Nomegestrol acetate is 3.34. |
| Q: What is the CAS number of Nomegestrol acetate? |
| A: CAS number of Nomegestrol acetate is 58652-20-3. |
| Q: What is the safety information for Nomegestrol acetate? |
| A: Safety information for Nomegestrol acetate: 61. |
| Q: What English synonyms does Nomegestrol acetate have? |
| A: English synonyms of Nomegestrol acetate: [(8S,9S,10R,13S,14S,17R)-17-acetyl-6,13-dimethyl-3-oxo-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate, EINECS 261-379-8, 6-Methyl-3,20-dioxo-19-norpregna-4,6-dien-17-yl acetate, Lutenyl, (17a)-17-Acetyl-6-methyl-3-oxoestra-4,6-dien-17-yl acetate, MFCD00941390, 17-Acetoxy-6-methyl-19-norpregna-4,6-diene-3,20-dione, Nomegestrol acetate, 19-normegestrol acetate. |
| Q: What is the InChIKey of Nomegestrol acetate? |
| A: InChIKey of Nomegestrol acetate is IIVBFTNIGYRNQY-YQLZSBIMSA-N. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |