139481-59-7
139481-59-7 structure
- Name: Candesartan
- Chemical Name: 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid
- CAS Number: 139481-59-7
- Molecular Formula: C24H20N6O3
- Molecular Weight: 440.454
- Catalog: API Circulatory system medication Antihypertensive drug
- Create Date: 2018-03-05 08:00:00
- Modify Date: 2026-06-30 17:14:34
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Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.Target: Angiotensin II Receptorcandesartan is indicated for the treatment of hypertension. Results from the CHARM study in the early 2000s demonstrated the morbidity and mortality reduction benefits of candesartan therapy in congestive heart failure. Thus, while ACE inhibitors are still considered first-line therapy in heart failure, candesartan can be used in combination with an ACE to achieve improved mortality and morbidity vs. an ACE alone and additionally is an alternative in patients intolerant of ACE inhibitor therapy.Candesartan (0.5 mg/kg) decreases blood pressure and inhibits AT1 binding in the subfornical organ (SFO), paraventricular nucleus of the hypothalamus (PVN), nucleus of the solitary tract (NTS) and area postrema (AP) in WKY rats. Candesartan (0.3 mg/kg) pretreatment decreases the infarct area by 31% in adult spontaneously hypertensive rats, reduces the CBF decrease at the peripheral area of ischemia and the cortical volume of severe ischemic lesion.
| Name | 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid |
|---|---|
| Synonyms |
Candestan Cilexetil Impurity G(Candestan)
3-((2'-(2H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-2-ethoxy-3H-benzo[d]imidazole-4-cboxylic acid [CS-VII (Acid) Candestan Cilexetil Impurity G (Candestan Acid) Candestan[CandestanCilexetilIntermediates] 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-Biphenyl]-4-yl)Methyl)-2-Ethoxy-1H-Benzo[d]iMidazole-7-Cboxylicacid Candestan (Candestan Cilexetil impurity G) CV-11974 (±)-2-Ethoxy-1-[[2’-(1H-tetrazol-5-y1)[1，l'-biphenyl]-4-y1]methyl]-1H-benzimidazole-7-eboxylic acid Candestan, 10 mM in DMSO Candestan Impurity G CandestanQ: What is Candestan Q: What is the CAS Number of Candestan Q: What is the storage condition of Candestan Q: What e the applications of Candestan 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazol-7-cboxylic acid 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-ethoxy-1H-benzo[d]iMidazole-7-cboxylic acid Candestan Solution, 1000ppm MFCD00864463 Cestan intermediates Candestan Base 2-Ethoxy-1-[2'-(1-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl-methyl]benzimidazole-7-cboxylicacidcyclohexyl-1-chloroethylcbonate candestan cilexetil impurity1364 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-cboxylic Acid (Candes 3-[[2'-(1H-Tetrazol-5-yl)biphenyl-4-yl]Methyl]-2-ethoxy-3H-benziMidazole-4- cboxylic Acid Candestan Cilexetil IMpurity G Candestan Solution, 100ppm Candestan Cilexetil Related Compound G (1-{[2''-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-2-ethoxybe 2-Ethoxy-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl] 1H-Benzimidazole-7-cboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl] Candestan (C8) Candestan - Bio-X Candestan (Atacand) 2-Ethoxy-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-benzimidazole-7-carboxylic Acid 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-cboxylic acid 2-ETHOXY-1-[[2'-(1H-TETRAZOL-5-YL)(1,1'-BIPHENYL)-4-YL]METHYL]-1H-BENZIMIDAZOLE-7-CBOXYLIC ACID Candestan Cilexetil Impurity 7 Impurity G) 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-cboxy tandishatan 2-ETHOXY(1H-TETRAZOL-5YL)1,1-BIPHENYL)-4-YL)-4-YL)METHYL)1H-BENZIMIDAZOLE-7-CBOXYLIC ACID 2-ethoxy-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid 2-ethoxy-1-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}Methyl)-1H-1,3-benzodiazole-7-cboxylic acid 2-Ethoxy-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylic acid Ratacand 1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-cboxylic acid CANDESTAN Amias Candestan //BP Candesartan Cilexetil Impurity 7 High Quality Intermediates Candestan CAS: 139-7 2-Ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid 2-Ethoxy-1-[[(2′-(1Htetrazol-5-Yl)Biphenyl-4-Yl-) Methyl]Benzimidazole-7-Cboxylic Acid CILEXITIL Candestan in methanol 2-(ethyloxy)-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-cboxylic 2-ethoxy-3-[[4-[2-(1h-tetrazol-5-yl)phenyl]phenyl]methyl]-3h-benzoimidazole-4-cboxylic acid 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-cboxylic Acid, CV-11974 Blopress 2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl] Atacend Candestan M1 2-Ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-cboxylic acid Candestan ( For Candestan Cilexetil ) Atacand 3-(2'-Cyano-biphenyl-4-ylMethyl)-2-ethoxy-3H-benzoiMidazole-4-cboxylic acid Me Candestan Cilexetil Impurity 7(Candestan Cilexetil Impurity G) Candestan Impurity -G Candestan Cilexetil Impurity G 2-Ethoxy-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylic acid Candestan Impurity-G Candestan Cilexetil Related Compound G |
| Description | Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.Target: Angiotensin II Receptorcandesartan is indicated for the treatment of hypertension. Results from the CHARM study in the early 2000s demonstrated the morbidity and mortality reduction benefits of candesartan therapy in congestive heart failure. Thus, while ACE inhibitors are still considered first-line therapy in heart failure, candesartan can be used in combination with an ACE to achieve improved mortality and morbidity vs. an ACE alone and additionally is an alternative in patients intolerant of ACE inhibitor therapy.Candesartan (0.5 mg/kg) decreases blood pressure and inhibits AT1 binding in the subfornical organ (SFO), paraventricular nucleus of the hypothalamus (PVN), nucleus of the solitary tract (NTS) and area postrema (AP) in WKY rats. Candesartan (0.3 mg/kg) pretreatment decreases the infarct area by 31% in adult spontaneously hypertensive rats, reduces the CBF decrease at the peripheral area of ischemia and the cortical volume of severe ischemic lesion. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 754.8±70.0 °C at 760 mmHg |
| Melting Point | 183-185°C |
| Molecular Formula | C24H20N6O3 |
| Molecular Weight | 440.454 |
| Flash Point | 410.3±35.7 °C |
| Exact Mass | 440.159698 |
| PSA | 118.81000 |
| LogP | 5.01 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.719 |
| Storage condition | -20°C Freezer |
| Hazard Codes | Xn: Harmful; |
|---|---|
| Risk Phrases | R20/21/22 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
| Precursor 9 | |
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| DownStream 3 | |
![ethyl 2-ethoxy-3-[[4-[2-(1-trityltetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate structure](https://image.chemsrc.com/caspic/466/856414-35-2.png)
![Methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate structure](https://image.chemsrc.com/caspic/430/136304-78-4.png)
![Methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-nitrobenzoate structure](https://image.chemsrc.com/caspic/116/139481-28-0.png)
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |