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145040-37-5

145040-37-5 structure
145040-37-5 structure
  • Name: Candesartan cilexetil
  • Chemical Name: Candesartan cilexetil
  • CAS Number: 145040-37-5
  • Molecular Formula: C33H34N6O6
  • Molecular Weight: 610.660
  • Catalog: API Circulatory system medication Antihypertensive drug
  • Create Date: 2018-03-05 08:00:00
  • Modify Date: 2026-07-01 06:37:42
  • Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.Target: Type-1 angiotensin II receptorCandesartan is generally well tolerated and significantly reduced cardiovascular deaths and hospital admissions for heart failure. Ejection fraction or treatment at baseline did not alter these effects [1]. In rats, TCV-116 inhibited the pressor responses to Ang I, Ang II, and Ang III without an effect on the bradykinin (BK)-induced depressor response. In SHR, the antihypertensive effect of TCV-116 (10 mg/kg) was larger than the maximum antihypertensive effect of enalapril and was not intensified by combination with enalapril. TCV-116 is more effective than enalapril in reducing blood pressure in SHR and 1K, 1C-HR, and that the BK- and/or prostaglandin-potentiating effect of enalapril contributes little to its antihypertensive mechanism in SHR [2].
Name Candesartan cilexetil
Synonyms exetiL
Candestan cilexetil for system suitability
2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-cboxylic Acid 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl Ester
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-cboxylate
High purity Antihypertensive Powder Candestan cilexetil CAS NO.145-5
Cadestan cilexetil
1-(Cyclohexyloxycbonyloxy)ethyl 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-ethoxy-1H-b
1-{[(Cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate
(+-)-1-Hydroxyethyl 2-ethoxy-1-[p-(o-1H-tetrazol-5-ylphenyl)l]-7-benzimidazolecboxylate, cyclohexyl cbonate (ester)
Candestan cilexetil an ATR antagonist
1-(((cyclohexyloxy)carbonyl)oxy)ethylester,(+-)-henyl)-4-yl)methyl)
1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-benzimidazole-7-cboxylate
2-ETHOXY-3-[2''-(1H-TETRAZOL-5-YL)-BIPHENYL-4-YLMETHYL]-3H-BENZOIMIDAZOLE-4-CBOXYLIC ACID 1-CYCLOHEXYLOXYCBONYLOXY-ETHYL ESTER
1h-benzimidazole-7-cboxylicacid,2-ethoxy-1-((2’-(1h-tetrazol-5-yl)(1,1’-bip
CandestanCilexetilMin
Candestan cilexetil for system suitability (Y0001389)Q: What is Candestan cilexetil for system suitability (Y0001389) Q: What is the CAS Number of Candestan cilexetil for system suitability (Y0001389)
2-ethoxy-3-[4-[2-(2H-tetrazol-5-yl)phenyl]benzyl]benzimidazole-4-cboxylic acid 1-(cyclohexoxycbonyloxy)ethyl ester
Candestan Cilexetil (C11)
Candestan Celexetil Ester
1H-Benzimidazole-7-cboxylic acid, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl ester
Candestan cilexetil for peak identification (Y0001387)
Candestan cilexeti
candestan cilexetil impurity1363
2-Ethoxy-1-[(2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-7-benzimidazolecboxylic acid 1-(cyclohexyloxycbonyloxy)ethyl ester
1H-Benzimidazole-7-cboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
Candestan cilexetil for system suitability CRS
Calldestan Cilexetil
Candestan Cilexetil >
Candestanciletexil
Candesttan
Candestan Cilexetil
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-et
Candestan cilexetilQ: What is Candestan cilexetil Q: What is the CAS Number of Candestan cilexetil Q: What is the storage condition of Candestan cilexetil Q: What e the applications of Candestan cilexetil
2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl Ester
2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4
Candestan Cilexetil API
2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-cboxylic acid-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
Candestan CiL
1-(((cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-cboxylate
Candesantan Cilexetil
Candestan cilexetil CRS
CANDESTAN CILEXITIL
Candesartan (Cilexetil)
tcv116
1H-Benzimidazole-7-cboxylic acid, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester, (+-)
1-cyclohexyloxycbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-cboxylate
UNII:R85M2X0D68
Candestan cilexetil for peak identification CRS
MFCD00871371
1-{[(Cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylate
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2
{[(Cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy- 1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}- 1H-benzimidazole-7-cboxylate
1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate
Blopress
Candestan Cilexetil 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1H- tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7- cboxylate
Candestan cilexetil for peak identification
Atacand
Candestan cilexetil //BP
Candestan Cilexetil (Y0001388)Q: What is Candestan Cilexetil (Y0001388) Q: What is the CAS Number of Candestan Cilexetil (Y0001388)
1-cyclohexyloxycbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-cboxylate
1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
Description Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.Target: Type-1 angiotensin II receptorCandesartan is generally well tolerated and significantly reduced cardiovascular deaths and hospital admissions for heart failure. Ejection fraction or treatment at baseline did not alter these effects [1]. In rats, TCV-116 inhibited the pressor responses to Ang I, Ang II, and Ang III without an effect on the bradykinin (BK)-induced depressor response. In SHR, the antihypertensive effect of TCV-116 (10 mg/kg) was larger than the maximum antihypertensive effect of enalapril and was not intensified by combination with enalapril. TCV-116 is more effective than enalapril in reducing blood pressure in SHR and 1K, 1C-HR, and that the BK- and/or prostaglandin-potentiating effect of enalapril contributes little to its antihypertensive mechanism in SHR [2].
Related Catalog
References

[1]. Pfeffer, M.A., et al., Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet, 2003. 362(9386): p. 759-66.

[2]. Wada, T., et al., Comparison of the antihypertensive effects of the new angiotensin II (AT1) receptor antagonist candesartan cilexetil (TCV-116) and the angiotensin converting enzyme inhibitor enalapril in rats. Hypertens Res, 1996. 19(2): p. 75-81.
Density 1.4±0.1 g/cm3
Boiling Point 843.3±75.0 °C at 760 mmHg
Melting Point 168-170?C
Molecular Formula C33H34N6O6
Molecular Weight 610.660
Flash Point 463.8±37.1 °C
Exact Mass 610.253967
PSA 143.34000
LogP 7.79
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.667
Storage condition -20°C Freezer
Symbol GHS08 GHS09
GHS08, GHS09
Signal Word Warning
Hazard Statements H361-H400
Precautionary Statements P280
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases 26-36
RIDADR NONH for all modes of transport
HS Code 2933990090
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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