Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1H-Benzimidazole,5,6-dichloro-1-b-D-ribofuranosyl-
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53-85-0

53-85-0 structure

Name: 5,6-Dichlorobenzimidazole riboside
Chemical Name: 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole
CAS Number: 53-85-0
Molecular Formula: C₁₂H₁₂Cl₂N₂O₄
Molecular Weight: 319.141
Catalog: Biochemical Carbohydrate Monosaccharide
Create Date: 2018-12-28 10:24:02
Modify Date: 2026-06-30 08:07:51
5,6-Dichlorobenzimidazole riboside is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II and CDKs[1][2][3][4]. 5,6-Dichlorobenzimidazole riboside trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells[5].

Name	5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole
Synonyms	5,6-dichloro-1-beta-d-ribofuranosyl-benzimidazol 5,6-Dichlorobenzimidazole-1-b-D-ribofuranoside 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - - Calbiochem 5,6-dichloro-1-β-D-ribobenzimidazole 1H-Benzimidazole, 5,6-dichloro-1-β-D-ribofuranosyl- (9CI) 5,6-Dichloropurine-1-D-ribofuanosyl-H-benzimidazole 5,6-dichlorobenzimidazole 1-β-d-ribofuranoside 5,6-Dichloro-1-(β-D-ribofuranosyl)-1H-benzimidazole 1H-Benzimidazole, 5,6-dichloro-1-β-D-ribofuranosyl 1-β-D-Ribofuranosyl-5,6-dichlorobenziMidazole DRB (Benzimidazole) 5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside DRB1 DBR, 5,6-Dichlorobenzimidazole 1-D-ribofuranoside 5,6-DICHLORO-BETA-D-RIBOFURANOSYL-BENZIMIDAZOLE 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole, 5,6-Dichlorobenzimidazole riboside, DRB MFCD00036785 5,6-DICHLORO-1-BETA-D-RIBOFURANOSYLBENZIMIDAZOLE 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole DRB (Benzimidazole), Casein kinase II inhibitor 5,6-DICHLOROPURINE-1-BETA-D-RIBOFURANOSYL-H-BENZIMIDAZOLE Elab Fluor Red 780 Anti-Human HLA-DR Antibody[L243 5,6-Dichlorobenzimidazole1-β-D-Ribofuranoside> DR beta 3 5,6-dichlorobenzimidazoleriboside(drb) 5,6-DICHLOROBENZIMIDAZOLE RIBOSIDE DR beta DR beta 1 1H-Benzimidazole,5,6-dichloro-1-b-D-ribofuranosyl 5,6-DICHLOROBENZIMIDAZOLE RIBOSIDE (DRB) Dichlorobenzimidazoleribofuranoside 5,6-Dichlorobenzimidazole riboside,DRB,inhibit,Inhibitor,CDK,Cyclin dendent kinase 6-Dichlorobenzimidazole 1-β-D-Ribofuranoside DRB //BP 5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole DBR,5,6-Dichlorobenzimidazole1-b-D-ribofuranoside 5,6-Dichloro-1-(beta-D-ribofuranosyl)-1H-benzimidazole 5,6-Dichlorobenzimidazole 1-β- D -ribofuranoside 4,5-dichloro-2-(3-methylbenzyl)pyridazin-3(2h)-one 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole DRB, 10 mM in DMSO 5,6-Dichloropurine-1-Beta-D-ribofuanosyl-H-benzimidazole 5,6-Dichlororibofuranosylbenzimidazole 5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole 5,6-Dichloropurine-1-b-D-ribofuanosyl-H-benzimidazole (2R,3R,4S,5R)-2-(5,6-Dichloro-1H-benzo[d]imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol DRB 5,6-DICHLOROBENIMIDAZOLE-1-B-D- RIBOFURANOSIDE 5,6-Dichlorobenzimidazole-1-β-D-ribofuranoside 5,6-DICHLOROBENZIMIDAZOLE-1-BETA-D-RIBOFURANOSIDE dichlororibofuranosylbenzimidazole HLA-DR1B 5,6-Dichlorobenzimidazole riboside(DBR) HLA-DRB

Description	5,6-Dichlorobenzimidazole riboside is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II and CDKs[1][2][3][4]. 5,6-Dichlorobenzimidazole riboside trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells[5].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
References	[1]. Zandomeni RO. Kinetics of inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole on calf thymus casein kinase II. Biochem J. 1989 Sep 1;262(2):469-73. [2]. Yankulov K, et al. The transcriptional elongation inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase. J Biol Chem. 1995 Oct 13;270(41):23922-5. [3]. Rickert P, et al. Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases. Oncogene. 1999 Jan 28;18(4):1093-102. [4]. Schang LM. Cyclin-dependent kinases as cellular targets for antiviral drugs. J Antimicrob Chemother. 2002 Dec;50(6):779-92. [5]. te Poele RH, et al. RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells. Oncogene. 1999 Oct 14;18(42):5765-72.

Density	1.8±0.1 g/cm3
Boiling Point	606.2±65.0 °C at 760 mmHg
Melting Point	222-224ºC
Molecular Formula	C₁₂H₁₂Cl₂N₂O₄
Molecular Weight	319.141
Flash Point	320.4±34.3 °C
Exact Mass	318.017426
PSA	87.74000
LogP	2.05
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.750
Storage condition	−20°C
Water Solubility	Soluble in DMSO to 75mMSoluble in dimethyl sulfoxide, hot ethanol, dimethyl formamide, (1:2) dimethyl formamide:Phosphate buffer saline, water, methanol and pyridine. Slightly soluble in aqueous buffers.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD7310000

CHEMICAL NAME :: Benzimidazole, 5,6-dichloro-1-beta-D-ribofuranosyl-

CAS REGISTRY NUMBER :: 53-85-0

BEILSTEIN REFERENCE NO. :: 0039123

LAST UPDATED :: 199806

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H12-Cl2-N2-O4

MOLECULAR WEIGHT :: 319.16

WISWESSER LINE NOTATION :: T56 BN DNJ GG HG B- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 40 umol/L

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 79,2569,1982

Safety Phrases	24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DD7310000
HS Code	29349990

Precursor 5
6478-73-5 5348-42-5 19462-98-7 142356-78-3
6974-32-9
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