53-85-0

53-85-0 structure

Name: 5,6-Dichlorobenzimidazole riboside
Chemical Name: 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole
CAS Number: 53-85-0
Molecular Formula: C₁₂H₁₂Cl₂N₂O₄
Molecular Weight: 319.141
Catalog: Biochemical Carbohydrate Monosaccharide
Create Date: 2018-12-28 10:24:02
Modify Date: 2024-01-02 16:47:15
5,6-Dichlorobenzimidazole riboside is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II and CDKs[1][2][3][4]. 5,6-Dichlorobenzimidazole riboside trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells[5].

Name	5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole
Synonyms	1H-Benzimidazole, 5,6-dichloro-1-β-D-ribofuranosyl- 1H-Benzimidazole, 5,6-dichloro-1-β-D-ribofuranosyl- (9CI) Benzimidazole, 5,6-dichloro-1-β-D-ribofuranosyl- 5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole 5,6-Dichloro-1-(β-D-ribofuranosyl)-1H-benzimidazole DRB 5,6-Dichlorobenzimidazole riboside 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole MFCD00036785 5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside

Description	5,6-Dichlorobenzimidazole riboside is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II and CDKs[1][2][3][4]. 5,6-Dichlorobenzimidazole riboside trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells[5].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
References	[1]. Zandomeni RO. Kinetics of inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole on calf thymus casein kinase II. Biochem J. 1989 Sep 1;262(2):469-73. [2]. Yankulov K, et al. The transcriptional elongation inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase. J Biol Chem. 1995 Oct 13;270(41):23922-5. [3]. Rickert P, et al. Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases. Oncogene. 1999 Jan 28;18(4):1093-102. [4]. Schang LM. Cyclin-dependent kinases as cellular targets for antiviral drugs. J Antimicrob Chemother. 2002 Dec;50(6):779-92. [5]. te Poele RH, et al. RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells. Oncogene. 1999 Oct 14;18(42):5765-72.

Density	1.8±0.1 g/cm3
Boiling Point	606.2±65.0 °C at 760 mmHg
Melting Point	222-224ºC
Molecular Formula	C₁₂H₁₂Cl₂N₂O₄
Molecular Weight	319.141
Flash Point	320.4±34.3 °C
Exact Mass	318.017426
PSA	87.74000
LogP	2.05
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.750
Storage condition	−20°C
Water Solubility	Soluble in DMSO to 75mMSoluble in dimethyl sulfoxide, hot ethanol, dimethyl formamide, (1:2) dimethyl formamide:Phosphate buffer saline, water, methanol and pyridine. Slightly soluble in aqueous buffers.

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 79,2569,1982

Safety Phrases	24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DD7310000
HS Code	29349990