5,6-Dichlorobenzimidazole riboside
5,6-Dichlorobenzimidazole riboside structure
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Common Name | 5,6-Dichlorobenzimidazole riboside | ||
|---|---|---|---|---|
| CAS Number | 53-85-0 | Molecular Weight | 319.141 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 606.2±65.0 °C at 760 mmHg | |
| Molecular Formula | C12H12Cl2N2O4 | Melting Point | 222-224ºC | |
| MSDS | Chinese USA | Flash Point | 320.4±34.3 °C | |
Use of 5,6-Dichlorobenzimidazole riboside5,6-Dichlorobenzimidazole riboside is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II and CDKs[1][2][3][4]. 5,6-Dichlorobenzimidazole riboside trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells[5]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | 5,6-Dichlorobenzimidazole riboside is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II and CDKs[1][2][3][4]. 5,6-Dichlorobenzimidazole riboside trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells[5]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 606.2±65.0 °C at 760 mmHg |
| Melting Point | 222-224ºC |
| Molecular Formula | C12H12Cl2N2O4 |
| Molecular Weight | 319.141 |
| Flash Point | 320.4±34.3 °C |
| Exact Mass | 318.017426 |
| PSA | 87.74000 |
| LogP | 2.05 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.750 |
| InChIKey | XHSQDZXAVJRBMX-DDHJBXDOSA-N |
| SMILES | OCC1OC(n2cnc3cc(Cl)c(Cl)cc32)C(O)C1O |
| Storage condition | −20°C |
| Water Solubility | Soluble in DMSO to 75mMSoluble in dimethyl sulfoxide, hot ethanol, dimethyl formamide, (1:2) dimethyl formamide:Phosphate buffer saline, water, methanol and pyridine. Slightly soluble in aqueous buffers. |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Safety Phrases | 24/25 |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DD7310000 |
| HS Code | 29349990 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 5 | |
|---|---|
| DownStream 0 | |
![5,6-Dichloro-1H-benzo[d]imidazole Structure](https://image.chemsrc.com/caspic/278/6478-73-5.png)
CAS#:6478-73-5
CAS#:5348-42-5
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CAS#:142356-78-3
CAS#:6974-32-9This table lists relevant public references with title, journal and publication metadata for this compound.
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Direct regulation of gonadotrophin-releasing hormone (GnRH) transcription by RF-amide-related peptide-3 and kisspeptin in a novel GnRH-secreting cell line, mHypoA-GnRH/GFP.
J. Neuroendocrinol. 26(12) , 888-97, (2014) RF-amide-related peptide-3 [RFRP-3; also often referred to as the mammalian orthologue of the avian gonadotrophin-inhibitory hormone (GnIH)] and kisspeptin have emerged as potent modulators of neuroen... |
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GSK-3β Phosphorylation of Cytoplasmic Dynein Reduces Ndel1 Binding to Intermediate Chains and Alters Dynein Motility.
Traffic 16 , 941-61, (2015) Glycogen synthase kinase 3 (GSK-3) has been linked to regulation of kinesin-dependent axonal transport in squid and flies, and to indirect regulation of cytoplasmic dynein. We have now found evidence ... |
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Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway.
Carcinogenesis 35(11) , 2534-43, (2014) Cytochrome P450 1B1 (CYP1B1) is an enzyme that has a unique tumor-specific pattern of expression and is capable of bioactivating a wide range of carcinogenic compounds. We have reported previously tha... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Inhibition of RNA polymerase II in mouse B16-F1 migrating cells assessed as fold chan...
Source: ChEMBL
Target: DNA-directed RNA polymerase II subunit RPB3
External Id: CHEMBL5677507
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Name: Inhibition of RNA polymerase II in mouse B16-F1 migrating cells assessed as fold chan...
Source: ChEMBL
Target: DNA-directed RNA polymerase II subunit RPB3
External Id: CHEMBL5677506
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Name: Inhibition of RNA polymerase II in mouse B16-F1 migrating cells assessed as fold chan...
Source: ChEMBL
Target: DNA-directed RNA polymerase II subunit RPB3
External Id: CHEMBL5677509
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Name: Inhibition of RNA polymerase II in mouse B16-F1 migrating cells assessed as fold chan...
Source: ChEMBL
Target: DNA-directed RNA polymerase II subunit RPB3
External Id: CHEMBL5677508
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Name: Inhibition of RNA polymerase II in mouse B16-F1 migrating cells assessed as fold chan...
Source: ChEMBL
Target: DNA-directed RNA polymerase II subunit RPB3
External Id: CHEMBL5677511
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Name: Inhibition of RNA polymerase II in mouse B16-F1 migrating cells assessed as fold chan...
Source: ChEMBL
Target: DNA-directed RNA polymerase II subunit RPB3
External Id: CHEMBL5677510
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Name: Inhibition of RNA polymerase II in mouse B16-F1 migrating cells assessed as fold chan...
Source: ChEMBL
Target: DNA-directed RNA polymerase II subunit RPB3
External Id: CHEMBL5677513
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Name: Inhibition of RNA polymerase II in mouse B16-F1 migrating cells assessed as fold chan...
Source: ChEMBL
Target: DNA-directed RNA polymerase II subunit RPB3
External Id: CHEMBL5677512
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Name: Inhibition of RNA polymerase II in mouse B16-F1 migrating cells assessed as fold chan...
Source: ChEMBL
Target: DNA-directed RNA polymerase II subunit RPB3
External Id: CHEMBL5677515
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Name: Compound was evaluated for the visual cytotoxicity scored on HFF cells at time of HCM...
Source: ChEMBL
Target: HFF
External Id: CHEMBL694723
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 1H-Benzimidazole, 5,6-dichloro-1-β-D-ribofuranosyl- (9CI) |
| 5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole |
| 5,6-Dichloro-1-(β-D-ribofuranosyl)-1H-benzimidazole |
| DRB |
| 5,6-Dichlorobenzimidazole riboside |
| 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole |
| MFCD00036785 |
| 5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: How is the water solubility of 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole? |
| A: Water solubility of 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole: Soluble in DMSO to 75mMSoluble in dimethyl sulfoxide, hot ethanol, dimethyl formamide, (1:2) dimethyl formamide:Phosphate buffer saline, water, methanol and pyridine. Slightly soluble in aqueous buffers. |
| Q: What is the polar surface area (PSA) of 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole? |
| A: Polar surface area (PSA) of 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole is 87.74000. |
| Q: What is the CAS number of 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole? |
| A: CAS number of 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole is 53-85-0. |
| Q: What is the molecular weight of 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole? |
| A: Molecular weight of 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole is 319.141. |
| Q: What is the molecular formula of 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole? |
| A: Molecular formula of 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole is C12H12Cl2N2O4. |
| Q: What is the safety information for 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole? |
| A: Safety information for 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole: 24/25. |
| Q: What are the storage conditions for 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole? |
| A: Storage conditions for 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole: −20°C. |
| Q: What is the SMILES notation of 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole? |
| A: SMILES notation of 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole is OCC1OC(n2cnc3cc(Cl)c(Cl)cc32)C(O)C1O. |
| Q: What English synonyms does 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole have? |
| A: English synonyms of 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole: 1H-Benzimidazole, 5,6-dichloro-1-β-D-ribofuranosyl- (9CI), 5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole, 5,6-Dichloro-1-(β-D-ribofuranosyl)-1H-benzimidazole, DRB, 5,6-Dichlorobenzimidazole riboside, 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole, MFCD00036785, 5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside. |
| Q: What is the boiling point of 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole? |
| A: Boiling point of 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole is 606.2±65.0 °C at 760 mmHg. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |