79642-50-5
79642-50-5 structure
- Name: DSG Crosslinker
- Chemical Name: bis(2,5-dioxopyrrolidin-1-yl) pentanedioate
- CAS Number: 79642-50-5
- Molecular Formula: C13H14N2O8
- Molecular Weight: 326.259
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2018-07-24 05:48:55
- Modify Date: 2024-01-04 22:11:29
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DSG Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
| Name | bis(2,5-dioxopyrrolidin-1-yl) pentanedioate |
|---|---|
| Synonyms |
N,N'-disuccinimidyl glutarate
1,1'-[(1,5-Dioxo-1,5-pentanediyl)bis(oxy)]di(2,5-pyrrolidinedione) DISUCCINIMIDYL GLUTARATE 2,5-Pyrrolidinedione, 1,1'-[(1,5-dioxo-1,5-pentanediyl)bis(oxy)]bis- N-hydroxysuccinimide ester disuccinimidyl glutarate |
| Description | DSG Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | |
| Target |
Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 485.1±55.0 °C at 760 mmHg |
| Molecular Formula | C13H14N2O8 |
| Molecular Weight | 326.259 |
| Flash Point | 247.2±31.5 °C |
| Exact Mass | 326.075012 |
| PSA | 127.36000 |
| LogP | -3.30 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.572 |
| Storage condition | -20°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
|
~99%
79642-50-5 |
| Literature: Van Den Berg, Tieme A.; Feringa, Ben L.; Roelfes, Gerard Chemical Communications, 2007 , # 2 p. 180 - 182 |
