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Product Name: Diethylene glycol diacetate
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628-68-2

628-68-2 structure

628-68-2 structure

Name: Oxydiethan-2,1-diyldiacetat
Chemical Name: diethylene glycol diacetate
CAS Number: 628-68-2
Molecular Formula: C₈H₁₄O₅
Molecular Weight: 190.194
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-23 21:39:04
Modify Date: 2026-07-03 17:56:34
Diethylene glycol diacetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	diethylene glycol diacetate
Synonyms	Diethyleneglycol Diacetate BIS (2-ACETOXYETHYL) ETHER 2,2'-OXYBISETHANOL DIACETATE Ethanol, 2,2'-oxybis-, diacetate Diethylene Glycol Diacetate 2,2μ-Oxybisethanol diacetate, Bis(2-acetoxyethyl) ether, Oxydiethylene acetate Diglycol, diacetate Ethanol,2,2’-oxybis-,diacetate OXYBIS(2-ETHYL ACETATE) oxydiethylenedi(acetate) Diethyleneglycol diacetate Diethyleneglycol diacetate ISO 9001：2015 REACH aceticacid2-(2-acetoxy-ethoxy)-ethylester MFCD00026211 2,2'-Oxybis(ethanol acetate) 2-(2-acetyloxyethoxy)ethyl ethanoate CAS_-2 2-acetoxyethyl ether EINECS 211-049-4 2,2’-oxybis-ethanodiacetate digol diacetate iethyleneglycoldiacetate Diethylene glycol diacetate: (Diacetate-1,1 -oxybis-ethanol) Diethylene Glycol Diacetate > Oxydiethane-2,1-diyl diacetate DIETHYLENE GLYCOL DIACETATE OXYDIETHYLENE ACETATE Diacetic acid oxybisethylene ester 1,1'-Oxybis(2-acetoxyethane) Diethylene glycol, diacetate (8CI) aceticacid,oxydiethyleneester 2-[2-(Acetyloxy)ethoxy]ethyl acetate Ethanol, 2,2'-oxybis-, 1,1'-diacetate Oxydi-2,1-ethanediyl diacetate

Description	Diethylene glycol diacetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density	1.1±0.1 g/cm3
Boiling Point	248.0±0.0 °C at 760 mmHg
Melting Point	19°C
Molecular Formula	C₈H₁₄O₅
Molecular Weight	190.194
Flash Point	100.4±20.4 °C
Exact Mass	190.084122
PSA	61.83000
LogP	-0.08
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.424

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AJ1800000

CHEMICAL NAME :: Acetic acid, oxydiethylene ester

CAS REGISTRY NUMBER :: 628-68-2

BEILSTEIN REFERENCE NO. :: 1777856

LAST UPDATED :: 199806

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H14-O5

MOLECULAR WEIGHT :: 190.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10700 uL/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :: PRKHDK Problemi na Khigienata. Problems in Hygiene. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov 11, Sofia, Bulgaria) V.1- 1975- Volume(issue)/page/year: 3,25,1977

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36
Safety Phrases	S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AJ1800000
HS Code	2918990090

Precursor 10
108-24-7 111-46-6 123-91-1 64-19-7
75-64-9 127-09-3 111-44-4 141-78-6
75-36-5 463-51-4
DownStream 1
73727-30-7

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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