Oxydiethan-2,1-diyldiacetat

Modify Date: 2025-08-23 10:58:06

Oxydiethan-2,1-diyldiacetat Structure
Oxydiethan-2,1-diyldiacetat structure
Common Name Oxydiethan-2,1-diyldiacetat
CAS Number 628-68-2 Molecular Weight 190.194
Density 1.1±0.1 g/cm3 Boiling Point 248.0±0.0 °C at 760 mmHg
Molecular Formula C8H14O5 Melting Point 19°C
MSDS USA Flash Point 100.4±20.4 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Oxydiethan-2,1-diyldiacetat


Diethylene glycol diacetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name diethylene glycol diacetate
Synonym More Synonyms

 Oxydiethan-2,1-diyldiacetat Biological Activity

Description Diethylene glycol diacetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 248.0±0.0 °C at 760 mmHg
Melting Point 19°C
Molecular Formula C8H14O5
Molecular Weight 190.194
Flash Point 100.4±20.4 °C
Exact Mass 190.084122
PSA 61.83000
LogP -0.08
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.424

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AJ1800000
CHEMICAL NAME :
Acetic acid, oxydiethylene ester
CAS REGISTRY NUMBER :
628-68-2
BEILSTEIN REFERENCE NO. :
1777856
LAST UPDATED :
199806
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C8-H14-O5
MOLECULAR WEIGHT :
190.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10700 uL/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
REFERENCE :
PRKHDK Problemi na Khigienata. Problems in Hygiene. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov 11, Sofia, Bulgaria) V.1- 1975- Volume(issue)/page/year: 3,25,1977

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36
Safety Phrases S26
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS AJ1800000
HS Code 2918990090

 Synthetic Route

 Customs

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Diethyleneglycol diacetate
EINECS 211-049-4
Ethanol, 2,2'-oxybis-, diacetate
Diethylene glycol, diacetate (8CI)
Diethylene Glycol Diacetate
Oxydiethan-2,1-diyldiacetat
Oxydi-2,1-ethanediyl diacetate
Oxydiethane-2,1-diyl diacetate
MFCD00026211
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