Oxydiethan-2,1-diyldiacetat

Modify Date: 2026-07-03 17:56:34

Oxydiethan-2,1-diyldiacetat Structure
Oxydiethan-2,1-diyldiacetat structure
 Common Name Oxydiethan-2,1-diyldiacetat
CAS Number 628-68-2 Molecular Weight 190.194
Density 1.1±0.1 g/cm3 Boiling Point 248.0±0.0 °C at 760 mmHg
Molecular Formula C8H14O5 Melting Point 19°C
MSDS USA Flash Point 100.4±20.4 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Oxydiethan-2,1-diyldiacetat


Diethylene glycol diacetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name diethylene glycol diacetate
Synonym More Synonyms

 Oxydiethan-2,1-diyldiacetat Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Diethylene glycol diacetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.1±0.1 g/cm3
Boiling Point 248.0±0.0 °C at 760 mmHg
Melting Point 19°C
Molecular Formula C8H14O5
Molecular Weight 190.194
Flash Point 100.4±20.4 °C
Exact Mass 190.084122
PSA 61.83000
LogP -0.08
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.424
InChIKey UBPGILLNMDGSDS-UHFFFAOYSA-N
SMILES CC(=O)OCCOCCOC(C)=O

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AJ1800000
CHEMICAL NAME :
Acetic acid, oxydiethylene ester
CAS REGISTRY NUMBER :
628-68-2
BEILSTEIN REFERENCE NO. :
1777856
LAST UPDATED :
199806
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C8-H14-O5
MOLECULAR WEIGHT :
190.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10700 uL/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
REFERENCE :
PRKHDK Problemi na Khigienata. Problems in Hygiene. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov 11, Sofia, Bulgaria) V.1- 1975- Volume(issue)/page/year: 3,25,1977

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36
Safety Phrases S26
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS AJ1800000
HS Code 2918990090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Oxydiethan-2,1-diyldiacetatBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L...
Source: DTP/NCI
Target: N/A
External Id: MCF7_OneDose
Name: NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Non-Small Cell...
Source: DTP/NCI
Target: N/A
External Id: IGROV1_OneDose
Total 2, Current Page 1 of 1
1

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Diethyleneglycol diacetate
EINECS 211-049-4
Ethanol, 2,2'-oxybis-, diacetate
Diethylene glycol, diacetate (8CI)
Diethylene Glycol Diacetate
Oxydiethan-2,1-diyldiacetat
Oxydi-2,1-ethanediyl diacetate
Oxydiethane-2,1-diyl diacetate
MFCD00026211

 Oxydiethan-2,1-diyldiacetat | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the LogP of diethylene glycol diacetate?
A: LogP of diethylene glycol diacetate is -0.08.
Q: What is the boiling point of diethylene glycol diacetate?
A: Boiling point of diethylene glycol diacetate is 248.0±0.0 °C at 760 mmHg.
Q: What is the molecular formula of diethylene glycol diacetate?
A: Molecular formula of diethylene glycol diacetate is C8H14O5.
Q: What is the CAS number of diethylene glycol diacetate?
A: CAS number of diethylene glycol diacetate is 628-68-2.
Q: What is the melting point of diethylene glycol diacetate?
A: Melting point of diethylene glycol diacetate is 19°C.
Q: What is the InChIKey of diethylene glycol diacetate?
A: InChIKey of diethylene glycol diacetate is UBPGILLNMDGSDS-UHFFFAOYSA-N.
Q: What are the uses of diethylene glycol diacetate?
A: Main uses of diethylene glycol diacetate: Diethylene glycol diacetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Q: What is the SMILES notation of diethylene glycol diacetate?
A: SMILES notation of diethylene glycol diacetate is CC(=O)OCCOCCOC(C)=O.
Q: What are the upstream materials of diethylene glycol diacetate?
A: Related upstream materials(CAS) of diethylene glycol diacetate: 108-24-7;111-46-6;123-91-1;64-19-7;75-64-9;127-09-3;111-44-4;141-78-6;75-36-5;463-51-4.
Q: What are the downstream products of diethylene glycol diacetate?
A: Related downstream products(CAS) of diethylene glycol diacetate: 73727-30-7.

 Oxydiethan-2,1-diyldiacetatfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
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