382180-17-8

382180-17-8 structure

Name: N-Hydroxy-N'-(3-pyridinyl)octanediamide
Chemical Name: N'-hydroxy-N-pyridin-3-yloctanediamide
CAS Number: 382180-17-8
Molecular Formula: C₁₃H₁₉N₃O₃
Molecular Weight: 265.308
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Hydroxypyridine
Create Date: 2018-12-24 13:25:26
Modify Date: 2024-01-12 13:13:42
Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia.

Name	N'-hydroxy-N-pyridin-3-yloctanediamide
Synonyms	S2190_Selleck N-Hydroxy-N'-3-pyridinyloctanediamide N-Hydroxy-N'-(pyridin-3-yl)octanediamide N1-Hydroxy-N8-3-pyridinyl-octanediamide Octanediamide, N-hydroxy-N-3-pyridinyl- N-Hydroxy-N'-(3-pyridinyl)octanediamide pyroxamide N-Hydroxy-N'-3-pyridinyl octane diamide

Description	Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	ID50: 100 nM[1]
In Vitro	Pyroxamide (1.25-20.0 μM; 24-72 hours) suppresses RD and RH30B cells growth, pyroxamide resulted in 44% dead cells for 72 h at 20.0 μM, results in 86% dead cells in culture[1]. Pyroxamide (10.0-20.0 μM; 48 hours) shows sub-G1 fractions of 45.0% and 72.3% at 10.0 and 20.0 μM, respectively[1]. Cell Viability Assay[2] Cell Line: RD cells; RH30B cells Concentration: 1.25-20.0 μM Incubation Time: 24 hours; 48 hours; 72 hours Result: Resulted in a cell growth decrease in RD and RH30B cells. Cell Cycle Analysis[2] Cell Line: RD cells; RH30B cells Concentration: 10.0 μM; 20.0 μM Incubation Time: 48 hours Result: Increased the sub-G1 fractions at 48 hours compared with control samples.
References	[1]. Butler LM, et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin Cancer Res. 2001 Apr;7(4):962-70. [2]. Kutko MC, et al. Histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro.Clin Cancer Res. 2003 Nov 15;9(15):5749-55.

Density	1.2±0.1 g/cm3
Molecular Formula	C₁₃H₁₉N₃O₃
Molecular Weight	265.308
Exact Mass	265.142639
PSA	91.32000
LogP	0.04
Appearance	white to beige
Index of Refraction	1.570
Storage condition	?20°C
Water Solubility	DMSO: soluble10mg/mL (clear solution)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	22
RIDADR	NONH for all modes of transport
HS Code	2933399090

405096-07-3

~46%

382180-17-8

Literature: Remiszewski, Stacy W.; Sambucetti, Lidia C.; Atadja, Peter; Bair, Kenneth W.; Cornell, Wendy D.; Green, Michael A.; Howell, Kobporn Lulu; Jung, Manfred; Kwon, Paul; Trogani, Nancy; Walker, Heather Journal of Medicinal Chemistry, 2002 , vol. 45, # 4 p. 753 - 757

3946-32-5

382180-17-8

Precursor 2
405096-07-3 3946-32-5
DownStream 0

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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