Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: TERT-BUTYL (4-BROMOBUTYL)CARBAMATE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

164365-88-2

164365-88-2 structure

Name: Boc-NH-C4-Br
Chemical Name: tert-butyl N-(4-bromobutyl)carbamate
CAS Number: 164365-88-2
Molecular Formula: C₉H₁₈BrNO₂
Molecular Weight: 252.149
Catalog: Organic raw materials Amino compound Oxy-containing amino compound
Create Date: 2018-12-24 18:13:55
Modify Date: 2024-01-11 19:54:31
Boc-NH-C4-Br is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	tert-butyl N-(4-bromobutyl)carbamate
Synonyms	4-bromobutylamine tert-butylcarbamate N-Boc 4-bromobutan-1-amine tert-butyl 4-bromobutylcarbamate Carbamic acid, N-(4-bromobutyl)-, 1,1-dimethylethyl ester BrCH2CH2CH2CH2NHBoc 2-Methyl-2-propanyl (4-bromobutyl)carbamate MFCD06201020 N-(4-Bromobutyl)-Carbamic Acid 1,1-Dimethylethyl Ester tert-Butyl (4-bromobutyl)carbamate

Description	Boc-NH-C4-Br is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Hu R, et, al. Identification of a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor. Eur J Med Chem. 2022 Jan 5;227:113922.

Density	1.2±0.1 g/cm3
Boiling Point	308.8±25.0 °C at 760 mmHg
Molecular Formula	C₉H₁₈BrNO₂
Molecular Weight	252.149
Flash Point	140.5±23.2 °C
Exact Mass	251.052078
PSA	38.33000
LogP	2.78
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.473
Storage condition	2-8°C

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H318
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R41
Safety Phrases	S26-S39
RIDADR	NONH for all modes of transport
HS Code	2924199090

75178-87-9

~98%

164365-88-2

Literature: Simonin, Jonathan; Vernekar, Sanjeev Kumar V.; Thompson, Andrew J.; Hothersall, J. Daniel; Connolly, Christopher N.; Lummis, Sarah C.R.; Lochner, Martin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1151 - 1155

4509-90-4

75-65-0

~75%

164365-88-2

Literature: Bianco, Armandodoriano; Bonadies, Francesco; Napolitano, Raffaella; Ortaggi, Giancarlo Organic Preparations and Procedures International, 2004 , vol. 36, # 2 p. 141 - 149

236101-14-7

~89%

164365-88-2

Literature: Berree, Fabienne; Bazureau, Jean-Pierre; Michelot, Gwendal; Le Corre, Maurice Synthetic Communications, 1999 , vol. 29, # 15 p. 2685 - 2693

33977-38-7

24424-99-5

~66%

164365-88-2

Literature: Henig, Joerg; Mamedov, Ilgar; Fouskova, Petra; Toth, Eva; Logothetis, Nikos K.; Angelovski, Goran; Mayer, Hermann A. Inorganic Chemistry, 2011 , vol. 50, # 14 p. 6472 - 6481

24424-99-5

164365-88-2

Literature: Journal of the Chemical Society, Perkin Transactions 2, , # 5 p. 923 - 927

216959-34-1

164365-88-2

Literature: Synthetic Communications, , vol. 29, # 15 p. 2685 - 2693

174626-25-6

164365-88-2

Literature: Kim, Tae Woo; Park, Jung-hyun; Hong, Jong-In Journal of the Chemical Society, Perkin Transactions 2, 2002 , # 5 p. 923 - 927

Precursor 8
75178-87-9 4509-90-4 75-65-0 236101-14-7
33977-38-7 24424-99-5 216959-34-1 174626-25-6
DownStream 1
86953-79-9

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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