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56488-60-9

56488-60-9 structure
56488-60-9 structure
  • Name: Glutaurine
  • Chemical Name: (2S)-2-amino-5-oxo-5-(2-sulfoethylamino)pentanoic acid
  • CAS Number: 56488-60-9
  • Molecular Formula: C7H14N2O6S
  • Molecular Weight: 254.26
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2017-09-07 08:50:56
  • Modify Date: 2024-01-18 11:39:34
  • Glutaurine containing glutamine and taurine residues is an orally active hormone of the parathyroid. Glutaurine, as a hormone, is isolated from parathyroid gland oxyphil cells. Glutaurine can be used for the research of antiepileptic and anti-amnesia[1][2][3][4].
Name (2S)-2-amino-5-oxo-5-(2-sulfoethylamino)pentanoic acid
Synonyms Glutaurine
Litoralon
Glutaurin
g-l-glutamyltaurine
5-L-Glutamyl-taurine
5-Glutamyl-taurine
Description Glutaurine containing glutamine and taurine residues is an orally active hormone of the parathyroid. Glutaurine, as a hormone, is isolated from parathyroid gland oxyphil cells. Glutaurine can be used for the research of antiepileptic and anti-amnesia[1][2][3][4].
Related Catalog
In Vivo Glutaurine (1, 10, 20 or 50 μg/rat; p.o.) significantly restores the latency of entry in both the 24 and 48 hours tests at the dose of 50 μg/rat[2]. Glutaurine (100~3000 ug/kg; i.p.) significantly reduces T3 blood levels in a dose-dependent manner, but does not significantly raise T4 blood levels[3]. Animal Model: CFY male rats (170~250g)[2] Dosage: 1, 10, 20 or 50 μg/rat Administration: P.o. Result: Significantly restored the latency of entry in both the 24 and 48 h tests at the dose of 50 μg/rat. Animal Model: Fischer 344 rats[3] Dosage: 100~3000 ug/kg Administration: I.p. Result: Significantly reduced T3 blood levels in a dose-dependent manner, but did not significantly raise T4 blood levels.
References

[1]. Balázs M, et al. Effects of glutaurine treatment on electroshock-induced amnesia. Antiamnesic action of glutaurine. Neuropeptides. 1988;12(2):55-58.

[2]. Feuer L, et al. Effect of glutaurine, a newly discovered parathyroid hormone on rat thymus cultures. Acta Morphol Acad Sci Hung. 1978;26(2):87-94.

[3]. Baskin S, et al. The effect of glutaurine on thyroid hormones in the rat. Neuropeptides. 1987;9(1):45-50.

[4]. Uemura S, et al. Gamma-glutamyltaurine has potent and long-lasting antiepileptic action as demonstrated by intra-amygdaloid injection in amygdala-kindled rats. Brain Res. 1992;594(2):347-350.
Density 1.52g/cm3
Molecular Formula C7H14N2O6S
Molecular Weight 254.26
Exact Mass 254.05700
PSA 155.17000
LogP 0.35450
Index of Refraction 1.556
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA2290000
CHEMICAL NAME :
L-Glutamine, N-(2-sulfoethyl)-
CAS REGISTRY NUMBER :
56488-60-9
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H14-N2-O6-S
MOLECULAR WEIGHT :
254.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,110,1984
58238-09-8 structure

58238-09-8

~89%

56488-60-9 structure

56488-60-9

Literature: Higashiura; Ienaga Synthesis, 1992 , # 4 p. 353 - 354
56-85-9 structure

56-85-9

107-35-7 structure

107-35-7

~35%

56488-60-9 structure

56488-60-9

Literature: Tomita, Kenji; Yano, Toshihiro; Zhu, Jixi; Kumagai, Hidehiko; Tochikura, Tatsurokuro Agricultural and Biological Chemistry, 1989 , vol. 53, # 12 p. 3239 - 3244
30924-93-7 structure

30924-93-7

~%

56488-60-9 structure

56488-60-9

Literature: Higashiura, Kunihiko; Ienaga, Kazuharu Journal of Chemical Research, Miniprint, 1992 , p. 1901 - 1921
3705-42-8 structure

3705-42-8

~%

56488-60-9 structure

56488-60-9

Literature: Ienaga; Nakamura; Higashiura; Toyomaki; Kimura Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 8 p. 2796 - 2801
4821-78-7 structure

4821-78-7

~%

56488-60-9 structure

56488-60-9

Literature: Ienaga; Nakamura; Higashiura; Toyomaki; Kimura Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 8 p. 2796 - 2801
107-35-7 structure

107-35-7

142-47-2 structure

142-47-2

~25%

56488-60-9 structure

56488-60-9

Literature: Nakayama, Reiko; Kumagai, Hedehiko; Maruyama, Takashi; Tochikura, Tatsurokuro; Ueno, Tamio; Fukami, Hiroshi Agricultural and Biological Chemistry, 1981 , vol. 45, # l2 p. 2839 - 2846
4821-79-8 structure

4821-79-8

~%

56488-60-9 structure

56488-60-9

Literature: Ienaga; Nakamura; Higashiura; Toyomaki; Kimura Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 8 p. 2796 - 2801

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