66264-77-5

66264-77-5 structure

Name: Sulfinalol
Chemical Name: 4-[1-hydroxy-2-[4-(4-methoxyphenyl)butan-2-ylamino]ethyl]-2-methylsulfinylphenol
CAS Number: 66264-77-5
Molecular Formula: C₂₀H₂₇NO₄S
Molecular Weight: 377.50
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-02-16 08:00:00
Modify Date: 2024-01-04 17:50:29
Sulfinalol is an orally active β-adrenoceptor antagonist with direct vasodilator activity[1].

Name	4-[1-hydroxy-2-[4-(4-methoxyphenyl)butan-2-ylamino]ethyl]-2-methylsulfinylphenol
Synonyms	SULFINALOL Sulfinalolum

Description	Sulfinalol is an orally active β-adrenoceptor antagonist with direct vasodilator activity[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	β-adrenoceptor
In Vivo	Sulfinalol shows direct vasodilator activity and antihypertensive activity[1]. Animal Model: Mongrel dogs weighing 8.7-21.2 kg were anesthetized with pentobarbital (30-35 mg/kg, i.v., followed by a continuous infusion of 4 mg/kg/h)[1] Dosage: 0-100 µg Administration: Intraarterial injection Result: Increased blood flow in the sympathetically denervated hindlimb of anesthetized dogs. Animal Model: Male spontaneously hypertensive rats (SHR)[1] Dosage: 2.5 mg/kg Administration: Oral administration Result: Reduced pressure of conscious spontaneously hypertensive rats.
References	[1]. E J Sybertz, et al. Studies on the mechanism of the acute antihypertensive and vasodilator actions of several beta-adrenoceptor antagonists. J Cardiovasc Pharmacol. 1982 Sep-Oct;4(5):749-58.