2998-57-4
2998-57-4 structure
- Name: estramustine
- Chemical Name: estramustine
- CAS Number: 2998-57-4
- Molecular Formula: C23H31Cl2NO3
- Molecular Weight: 440.40300
- Catalog: API Antineoplastic agents Alkylating agent
- Create Date: 2018-03-31 08:00:00
- Modify Date: 2024-01-04 10:51:26
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Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts[1].
| Name | estramustine |
|---|---|
| Synonyms |
Estradiol 3-(N,N-bis(2-chloroethyl)carbamate)
[(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] N,N-bis(2-chloroethyl)carbamate Estramustina estradiol-3-bis(2-chloroethyl)carbamate Estramustinum MFCD00866377 Estracyt EINECS 221-076-3 17beta-Estradiol 3-(bis(2-chloroethyl)carbamate) |
| Description | Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts[1]. |
|---|---|
| Related Catalog | |
| Target |
Tubulin 1[1] |
| References |
| Density | 1.253 g/cm3 |
|---|---|
| Boiling Point | 565.8ºC at 760 mmHg |
| Melting Point | 104 - 105ºC |
| Molecular Formula | C23H31Cl2NO3 |
| Molecular Weight | 440.40300 |
| Flash Point | 296ºC |
| Exact Mass | 439.16800 |
| PSA | 49.77000 |
| LogP | 5.18200 |
| Vapour Pressure | 1.23E-13mmHg at 25°C |
| Index of Refraction | 1.576 |
| Hazard Codes | Xn |
|---|
|
~76%
2998-57-4 |
| Literature: Sk, Ugir Hossain; Dixit, Deobrat; Sen, Ellora European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 47 - 57 |
|
~%
2998-57-4 |
| Literature: Journal of medicinal chemistry, , vol. 10, # 2 p. 172 - 174 |
| Precursor 3 | |
|---|---|
| DownStream 2 | |
