Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Propanedioic acid,2-[(2-nitrophenyl)methylene]-, 1,3-dimethyl ester
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

65974-52-9

65974-52-9 structure

Name: Propanedioic acid,2-[(2-nitrophenyl)methylene]-, 1,3-dimethyl ester
Chemical Name: dimethyl 2-[(2-nitrophenyl)methylidene]propanedioate
CAS Number: 65974-52-9
Molecular Formula: C₁₂H₁₁NO₆
Molecular Weight: 265.21900
Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
Create Date: 2016-12-09 02:13:12
Modify Date: 2024-09-27 23:31:47
NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases[1].

Name	dimethyl 2-[(2-nitrophenyl)methylidene]propanedioate
Synonyms	HMS2882B21 2'-nitrobenzylidenemalonic acid dimethyl ester dimethyl 2-nitrobenzylidenemalonate ortho-nitrobenzylidenmalonsaeuredimethylester

Description	NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Inflammation/Immunology
References	[1]. Zhang S, et, al. Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors. Bioorg Med Chem. 2012 Oct 15;20(20):6073-9.

Density	1.335g/cm3
Boiling Point	361.7ºC at 760mmHg
Molecular Formula	C₁₂H₁₁NO₆
Molecular Weight	265.21900
Flash Point	151.8ºC
Exact Mass	265.05900
PSA	98.42000
LogP	1.84740
Index of Refraction	1.578

552-89-6

108-59-8

~97%

65974-52-9

Literature: Zhao, Xue Zhi; Smith, Steven J.; Metifiot, Mathieu; Johnson, Barry C.; Marchand, Christophe; Pommier, Yves; Hughes, Stephen H.; Burke Jr., Terrence R. Journal of Medicinal Chemistry, 2014 , vol. 57, # 4 p. 1573 - 1582

110-89-4

552-89-6

108-59-8

65974-52-9

Literature: Takeda Chemical Industries, Ltd. Patent: US6329389 B1, 2001 ;

Precursor 3
552-89-6 108-59-8 110-89-4
DownStream 1
103582-31-6

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