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1501-84-4

1501-84-4 structure
1501-84-4 structure
  • Name: Rimantadine Hydrochloride
  • Chemical Name: Rimantadine Hydrochloride
  • CAS Number: 1501-84-4
  • Molecular Formula: C12H22ClN
  • Molecular Weight: 215.763
  • Catalog: API Synthetic anti-infective drugs Antiviral drugs
  • Create Date: 2018-04-19 08:00:00
  • Modify Date: 2024-01-02 14:39:01
  • Rimantadine Hcl (Flumadine) is an anti-influenza virus drug.Target: Influenza VirusRimantadine are oral antiviral drugs useful in the prophylaxis and treatment of influenza A virus infections. rimantadine has prophylactic efficacy comparable to amantadine but lower potential for causing adverse effects [1]. double-blind study of children with influenza-like illness. 37 received rimantadine for five days. Of the total 37 children in the rimantadine group, 27% were found to have resistant isolated compared with 6% in the total group receiving acetaminophen (P < .04). Furthermore, the mean inhibitory concentration of rimantadine increased with time in the rimantadine group (r = .4, P = .002) [2].

Name Rimantadine Hydrochloride
Synonyms 1-(1-Adamantyl)ethylamine Hydrochloride
tricyclo[3.3.1.1]decane-1-methanamine, α-methyl-, hydrochloride
1-(Adamantan-1-yl)ethanamine hydrochloride (1:1)
a-Methyltricyclo[3.3.1.13,7]decane-1-methanamine Hydrochloride
Roflual
1-(tricyclo[3.3.1.1]dec-1-yl)ethanamine hydrochloride (1:1)
Meradan
Tricyclo[3.3.1.1]decane-1-methanamine, α-methyl-, hydrochloride (1:1)
α-Methyl-1-adamantanemethylamine hydrochloride
MFCD00072023
UNII:JEI07OOS8Y
a-Methyl-1-adamantanemethylamine Hydrochloride
1-(Adamantan-1-yl)ethanamine hydrochloride
1-Tricyclo[3.3.1.1]dec-1-ylethanaminhydrochlorid
Alpha-Methyl-1-Adamantanemethylamine Hydrochloride
1-(1-Aminoethyl)adamantane hydrochloride
Tricyclo[3.3.1.13,7]-decane-1-methanamine, .α.-methyl-, hydrochloride
Rimantadine Hydrochloride
1-tricyclo[3.3.1.1]déc-1-yléthanamine chlorhydrate
1-tricyclo[3.3.1.1]dec-1-ylethanamine hydrochloride
Remantadine hydrochloride
Description Rimantadine Hcl (Flumadine) is an anti-influenza virus drug.Target: Influenza VirusRimantadine are oral antiviral drugs useful in the prophylaxis and treatment of influenza A virus infections. rimantadine has prophylactic efficacy comparable to amantadine but lower potential for causing adverse effects [1]. double-blind study of children with influenza-like illness. 37 received rimantadine for five days. Of the total 37 children in the rimantadine group, 27% were found to have resistant isolated compared with 6% in the total group receiving acetaminophen (P < .04). Furthermore, the mean inhibitory concentration of rimantadine increased with time in the rimantadine group (r = .4, P = .002) [2].
Related Catalog
References

[1]. Hall, C.B., et al., Children with influenza A infection: treatment with rimantadine. Pediatrics, 1987. 80(2): p. 275-82.

[2]. Tominack, R.L. and F.G. Hayden, Rimantadine hydrochloride and amantadine hydrochloride use in influenza A virus infections. Infect Dis Clin North Am, 1987. 1(2): p. 459-78.

Boiling Point 247.8ºC at 760mmHg
Melting Point 300ºC
Molecular Formula C12H22ClN
Molecular Weight 215.763
Flash Point 99.3ºC
Exact Mass 215.144073
PSA 26.02000
LogP 4.05230
Vapour Pressure 0.0251mmHg at 25°C
Water Solubility Freely soluble in water.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU4717000
CHEMICAL NAME :
1-Adamantanemethylamine, alpha-methyl-, hydrochloride
CAS REGISTRY NUMBER :
1501-84-4
LAST UPDATED :
199803
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H21-N.Cl-H
MOLECULAR WEIGHT :
215.80
WISWESSER LINE NOTATION :
L66 B6/B-H/DI A B- C 1B ITJ BYZ1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
640 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 28(9),23,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
135 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,798,1977
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22
Safety Phrases 26-36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS AU4717000
HS Code 2921199090

~76%

1501-84-4 structure

1501-84-4

Literature: US4551552 A1, ;
Precursor  1

DownStream  2

HS Code 2921300090
Summary 2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%