Rimantadine Hydrochloride

Modify Date: 2024-01-02 14:39:01

Rimantadine Hydrochloride structure	Common Name	Rimantadine Hydrochloride
	CAS Number	1501-84-4	Molecular Weight	215.763
	Density	N/A	Boiling Point	247.8ºC at 760mmHg
	Molecular Formula	C₁₂H₂₂ClN	Melting Point	300ºC
	MSDS	Chinese USA	Flash Point	99.3ºC
	Symbol	GHS07	Signal Word	Warning

Use of Rimantadine Hydrochloride

Rimantadine Hcl (Flumadine) is an anti-influenza virus drug.Target: Influenza VirusRimantadine are oral antiviral drugs useful in the prophylaxis and treatment of influenza A virus infections. rimantadine has prophylactic efficacy comparable to amantadine but lower potential for causing adverse effects [1]. double-blind study of children with influenza-like illness. 37 received rimantadine for five days. Of the total 37 children in the rimantadine group, 27% were found to have resistant isolated compared with 6% in the total group receiving acetaminophen (P < .04). Furthermore, the mean inhibitory concentration of rimantadine increased with time in the rimantadine group (r = .4, P = .002) [2].

Name	Rimantadine Hydrochloride
Synonym	More Synonyms

Description	Rimantadine Hcl (Flumadine) is an anti-influenza virus drug.Target: Influenza VirusRimantadine are oral antiviral drugs useful in the prophylaxis and treatment of influenza A virus infections. rimantadine has prophylactic efficacy comparable to amantadine but lower potential for causing adverse effects [1]. double-blind study of children with influenza-like illness. 37 received rimantadine for five days. Of the total 37 children in the rimantadine group, 27% were found to have resistant isolated compared with 6% in the total group receiving acetaminophen (P < .04). Furthermore, the mean inhibitory concentration of rimantadine increased with time in the rimantadine group (r = .4, P = .002) [2].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection
References	[1]. Hall, C.B., et al., Children with influenza A infection: treatment with rimantadine. Pediatrics, 1987. 80(2): p. 275-82. [2]. Tominack, R.L. and F.G. Hayden, Rimantadine hydrochloride and amantadine hydrochloride use in influenza A virus infections. Infect Dis Clin North Am, 1987. 1(2): p. 459-78.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

References

[1]. Hall, C.B., et al., Children with influenza A infection: treatment with rimantadine. Pediatrics, 1987. 80(2): p. 275-82.

[2]. Tominack, R.L. and F.G. Hayden, Rimantadine hydrochloride and amantadine hydrochloride use in influenza A virus infections. Infect Dis Clin North Am, 1987. 1(2): p. 459-78.

Boiling Point	247.8ºC at 760mmHg
Melting Point	300ºC
Molecular Formula	C₁₂H₂₂ClN
Molecular Weight	215.763
Flash Point	99.3ºC
Exact Mass	215.144073
PSA	26.02000
LogP	4.05230
Vapour Pressure	0.0251mmHg at 25°C
Water Solubility	Freely soluble in water.

Rimantadine Hydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU4717000

CHEMICAL NAME :: 1-Adamantanemethylamine, alpha-methyl-, hydrochloride

CAS REGISTRY NUMBER :: 1501-84-4

LAST UPDATED :: 199803

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H21-N.Cl-H

MOLECULAR WEIGHT :: 215.80

WISWESSER LINE NOTATION :: L66 B6/B-H/DI A B- C 1B ITJ BYZ1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 28(9),23,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,798,1977

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AU4717000
HS Code	2921199090

1-adamantyl met...

CAS#:78679-71-7

~76%

Rimantadine Hyd...

CAS#:1501-84-4

Literature: US4551552 A1, ;

Precursor 1
CAS#:78679-71-7 1-adamantyl met...
DownStream 2
CAS#:90812-24-1 3-(1-aminoethyl... CAS#:128487-73-0 1-[1-[(1-amino-...

HS Code	2921300090
Summary	2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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Cys-Loop Receptor Channel Blockers Also Block GLIC

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The Gloeobacter ligand-gated ion channel (GLIC) is a bacterial homolog of vertebrate Cys-loop ligand-gated ion channels. Its pore-lining region in particular has a high sequence homology to these rela...

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Antibiot. Khimioter. 56(3-4) , 3-9, (2011)

The data on cytotoxicity and antiviral activity of commercial antivirals, such as Remantadine, Oseltamivir, Arbidol and Ribavirin in the MDCK cell culture infected with highly pathogenic (H5N1) and pa...

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UNII:JEI07OOS8Y

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China
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Dayang Chem (Hangzhou) Co., Ltd.
China
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Rimantadine Hydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
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