478288-90-3

478288-90-3 structure

Name: (R)-Bromoenol lactone
Chemical Name: (3R)-6-ethylidene-3-naphthalen-1-yloxan-2-one
CAS Number: 478288-90-3
Molecular Formula: C₁₆H₁₃BrO₂
Molecular Weight: 317.177
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
Create Date: 2016-05-24 07:18:27
Modify Date: 2024-01-05 22:41:55
(R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipaseγ(iPLA2γ)(/b). (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM[1].

Name	(3R)-6-ethylidene-3-naphthalen-1-yloxan-2-one
Synonyms	(3R,6E)-6-(Bromomethylene)-3-(1-naphthyl)tetrahydro-2H-pyran-2-one 2H-Pyran-2-one, 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-, (3R,6E)-

Description	(R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipaseγ(iPLA2γ)(/b). (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Others
References	[1]. Jenkins CM, et al. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s. J Biol Chem. 2002 Sep 6;277(36):32807-14.