Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-Amino-1,3-octadecanediol
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,3-Octadecanediol,2-amino-, (2S,3R)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

764-22-7

764-22-7 structure

764-22-7 structure

Name: 2-Amino-1,3-octadecanediol
Chemical Name: sphinganine
CAS Number: 764-22-7
Molecular Formula: C₁₈H₃₉NO₂
Molecular Weight: 301.508
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
Create Date: 2017-12-21 00:55:32
Modify Date: 2024-01-09 11:30:20
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

Name	sphinganine
Synonyms	erythro-Sphinganine D-erythro-Sphinganine 2-Aminooctadecane-1,3-diol Dihydro-C18-sphingosine (2S,3R)-2-aminooctadecane-1,3-diol D-erythro-2-Amino-1,3-octadecanediol 2-Amino-1,3-dihydroxyoctadecane DL-erythro-2-Amino-1,3-octadecanediol 1,3-Octadecanediol, 2-amino- 2-Amino-1,3-octadecanediol Octadephinganine D-erythro-C18-Dihydrosphingosine C18-Dihydrosphingosine Dihydrosphingosine DL-erythro-1,3-Dihydroxy-2-aminooctadecane

Description	D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Cancer Natural Products >> Others
Target	Human Endogenous Metabolite
In Vitro	D-Erythro-dihydrosphingosine (D-erythro-DHS) significantly inhibits mastoparan-, but not Na3VO4-, stimulated arachidonic acid release in PC12 cells. D-Erythro-dihydrosphingosine at 100 AM slightly inhibits [3H]Arachidonic acid release, and 5 μM Ionomycin alone stimulates the release significantly. In the presence of 5 μM Ionomycin, 100 μM C2-ceramide stimulates the release, but D-Erythro-dihydrosphingosine (100 μM) inhibits the release. D-Erythro-dihydrosphingosine inhibits arachidonic acid release in cells and/or cPLA2α activity[1].
References	[1]. Nakamura H, et al. Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine. Eur J Pharmacol. 2004 Jan 19;484(1):9-17.

Density	0.9±0.1 g/cm3
Boiling Point	446.2±25.0 °C at 760 mmHg
Melting Point	70-72ºC
Molecular Formula	C₁₈H₃₉NO₂
Molecular Weight	301.508
Flash Point	223.7±23.2 °C
Exact Mass	301.298065
PSA	66.48000
LogP	6.27
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.478
Storage condition	-20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

Precursor 8
123-78-4 137410-26-5 140408-14-6 865355-31-3
1463440-03-0 105617-34-3 1424360-98-4 131606-77-4
DownStream 8
50-00-0 64-18-6 629-80-1 7664-41-7
57-10-3 1002-84-2 13031-64-6 118106-53-9

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