764-22-7
764-22-7 structure
- Name: 2-Amino-1,3-octadecanediol
- Chemical Name: sphinganine
- CAS Number: 764-22-7
- Molecular Formula: C18H39NO2
- Molecular Weight: 301.508
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
- Create Date: 2017-12-21 00:55:32
- Modify Date: 2024-01-09 11:30:20
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D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.
| Name | sphinganine |
|---|---|
| Synonyms |
erythro-Sphinganine
D-erythro-Sphinganine 2-Aminooctadecane-1,3-diol Dihydro-C18-sphingosine (2S,3R)-2-aminooctadecane-1,3-diol D-erythro-2-Amino-1,3-octadecanediol 2-Amino-1,3-dihydroxyoctadecane DL-erythro-2-Amino-1,3-octadecanediol 1,3-Octadecanediol, 2-amino- 2-Amino-1,3-octadecanediol Octadephinganine D-erythro-C18-Dihydrosphingosine C18-Dihydrosphingosine Dihydrosphingosine DL-erythro-1,3-Dihydroxy-2-aminooctadecane |
| Description | D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | D-Erythro-dihydrosphingosine (D-erythro-DHS) significantly inhibits mastoparan-, but not Na3VO4-, stimulated arachidonic acid release in PC12 cells. D-Erythro-dihydrosphingosine at 100 AM slightly inhibits [3H]Arachidonic acid release, and 5 μM Ionomycin alone stimulates the release significantly. In the presence of 5 μM Ionomycin, 100 μM C2-ceramide stimulates the release, but D-Erythro-dihydrosphingosine (100 μM) inhibits the release. D-Erythro-dihydrosphingosine inhibits arachidonic acid release in cells and/or cPLA2α activity[1]. |
| References |
| Density | 0.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 446.2±25.0 °C at 760 mmHg |
| Melting Point | 70-72ºC |
| Molecular Formula | C18H39NO2 |
| Molecular Weight | 301.508 |
| Flash Point | 223.7±23.2 °C |
| Exact Mass | 301.298065 |
| PSA | 66.48000 |
| LogP | 6.27 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.478 |
| Storage condition | -20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
![N-[(1S,2R)-2-Hydroxy-1-(hydroxyMethyl)heptadecyl]carbamic Acid 1,1-Dimethylethyl Ester structure](https://image.chemsrc.com/caspic/166/140408-14-6.png)
![(2S,3R)-2-[(tert-butoxycarbonyl)amino]-1,2-O-N-isopropylideneoctadecane-1,3-diol structure](https://image.chemsrc.com/caspic/407/131606-77-4.png)
