909400-43-7

909400-43-7 structure

Name: Cl-HIBO
Chemical Name: 2-amino-3-(4-chloro-3-oxo-1,2-oxazol-5-yl)propanoic acid
CAS Number: 909400-43-7
Molecular Formula: C₆H₇ClN₂O₄
Molecular Weight: 206.58400
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2016-04-25 16:30:04
Modify Date: 2024-01-04 17:12:43
Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties[1].

Name	2-amino-3-(4-chloro-3-oxo-1,2-oxazol-5-yl)propanoic acid
Synonyms	Cl-HIBO 4-CHLOROHOMOIBOTENIC ACID

Description	Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	EC50: 4.7, 1.7, 2700 and 1300 μM=GluR1/2/3/4[1]
In Vitro	Cl-HIBO is a strongly desensitizing full agonist at GluR1[1].
References	[1]. Bjerrum EJ, et al. Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). J Med Chem. 2003;46(11):2246-2249.