Cl-HIBO

Modify Date: 2025-08-27 12:40:18

Cl-HIBO Structure
Cl-HIBO structure
Common Name Cl-HIBO
CAS Number 909400-43-7 Molecular Weight 206.58400
Density N/A Boiling Point N/A
Molecular Formula C6H7ClN2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cl-HIBO


Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties[1].

 Names

Name 2-amino-3-(4-chloro-3-oxo-1,2-oxazol-5-yl)propanoic acid
Synonym More Synonyms

 Cl-HIBO Biological Activity

Description Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties[1].
Related Catalog
Target

EC50: 4.7, 1.7, 2700 and 1300 μM=GluR1/2/3/4[1]

In Vitro Cl-HIBO is a strongly desensitizing full agonist at GluR1[1].
References

[1]. Bjerrum EJ, et al. Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). J Med Chem. 2003;46(11):2246-2249.

 Chemical & Physical Properties

Molecular Formula C6H7ClN2O4
Molecular Weight 206.58400
Exact Mass 206.00900
PSA 109.58000
LogP 0.68830

 Synonyms

Cl-HIBO
4-CHLOROHOMOIBOTENIC ACID
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