67324-99-6

67324-99-6 structure

Name: 5-Iminodaunorubicin
Chemical Name: 12-Iminodaunorubicin HCl
CAS Number: 67324-99-6
Molecular Formula: C₂₇H₃₁ClN₂O₉
Molecular Weight: 562.99600
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2016-04-09 04:46:12
Modify Date: 2024-01-09 12:51:10
5-Iminodaunorubicin hydrochloride is a quinone-modified anthracycline that retains antitumor activity[1]. 5-Iminodaunorubicin hydrochloride produces protein-concealed DNA strand breaks in cancer cells[2].

Name	12-Iminodaunorubicin HCl
Synonyms	5-iminodaunorubicin hydrochloride aromatic/heteroaromatic sulfonamide 14 5-Imino-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-sulfonsaeure-amid 5-imino-4-methyl-4,5-dihydro-[1,3,4]thiadiazole-2-sulfonic acid amide 5-iminodaunomycin hydrochloride 1,3,4-Thiadiazole-2-sulfonamide,4,5-dihydro-5-imino-4-methyl

Description	5-Iminodaunorubicin hydrochloride is a quinone-modified anthracycline that retains antitumor activity[1]. 5-Iminodaunorubicin hydrochloride produces protein-concealed DNA strand breaks in cancer cells[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	In mouse leukemia L1210 cells, 5-Iminodaunorubicin produces protein-concealed DNA strand breaks. Many of the 5-iminodaunorubicin breaks may arise from apposed single-strand breaks (i.e., double-strand breaks)[2].
In Vivo	In rat, 5-Iminodaunorubicin (5-ID; 1-16 mg/kg) treatment produces widening of the QRS complex, increased R- and S-wave voltage, and prolonged the Q alpha T interval. And the quinone redox cycling is suppressed in 5-Iminodaunorubicin. 5-Iminodaunorubicin shows lower cardiotoxic[1].
References	[1]. R A Jensen, et al. Electrocardiographic and transmembrane potential effects of 5-iminodaunorubicin in the rat. Cancer Res. 1984 Sep;44(9):4030-9. [2]. L A Zwelling, et al. Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'-(9-acridinylamino)methanesulfon-m-anisidide. Cancer Res. 1982 Jul;42(7):2687-91.