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151-18-8

151-18-8 structure
151-18-8 structure
  • Name: Z2CN
  • Chemical Name: β-aminopropionitrile
  • CAS Number: 151-18-8
  • Molecular Formula: C3H6N2
  • Molecular Weight: 70.093
  • Catalog: Chemical reagent Organic reagent Cyanide/nitrile
  • Create Date: 2018-04-03 08:00:00
  • Modify Date: 2026-06-29 16:20:28
  • β-Aminopropionitrile is a specific and irreversible lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes[1][2].
Name β-aminopropionitrile
Synonyms 3-Amino-1-propanethiolHCl
3-amino-propionitrile
3-mercapto-1-propylamino hydrochloride
3-Mercaptopropylamine hydrochloride
BETA-AMINOETHYL CYANIDE
MFCD00014820
beta-Alaninenitrile
βAminopropionitrile,BAPN,insulin,Monoamine Oxidase,β Aminopropionitrile,inhibit,GLUT4,lysyl oxidase,Inhibitor,β-Aminopropionitrile,SiHa,obesity,cervical ccinoma cells,Endogenous Metabolite,thoracic aortic dissection,MAO,HeLa
( with K2CO3)
β-Aminopropanenitrile
3-Aminopropionitrile D4
3-thiopropylamine hydrochloride
homocysteamine hydrochloride
B-AMINOPROPIONITRILE
3-aminopropanethiol hydrochloride
3-AMINOPROPIONITRILE , WITH POTASSIUM CBONATE
beta-Aminopropionitrile
EINECS 205-786-0
3-cyanoethylamine
3-aminopropanonitrile
3-AMINOPROPIONITRILE STAB. WITH POTASSIUM CBONATE
Propionitrile, 3-amino
beta-Cyanoethylamine
3-Aminopropionitrile ( with K2CO3)
3-AMINOPROPANENITRILE
AMINOPROPIONITRILE
3-AMinopropionitrile
ized with K2CO3)
3-AMINOPROPIONITRILE (BETA-)
BETA-AMINOPROPIONONITRILE
N-(2-Cyanoethyl)amine
beta-aminopropionitrile
1-Propanethiol,3-aMino-,hydrochloride
3-Aminopropionitrile (stab. with potassium cbonate)
3-Aminopropanenitrile
3-AMINOPROPIONONITRILE
Propanenitrile, 3-amino
e (stabiL
3-AMinopropionitrile, , R
2-CYANOETHYLAMINE
3-AminopropionitriL
3-Aminopropionitrile ( with K2CO3)>
chlorhydrate de mercapto-3 propylamine
3-Aminopropionitrile
2-Cyanoethylamine
beta-Alaminenitrile
β-Aminopropionitrite
3-Aminopropionitrile Fumarate
N-(2-CYANOETHYL)AMINE
3-Aminopropiononitril
aminopropylthiol hydrochloride
β-Aminopropionitrile
β-Aminopropionitrile(BAPN)
aminoethylcyanide
Description β-Aminopropionitrile is a specific and irreversible lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes[1][2].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro β-Aminopropionitrile blocks the hypoxia-induced EMT morphological and marker protein changes, and inhibited invasion and migration capacities of cervical carcinoma cells in vitro[2].
References

[1]. Miana M, et al. The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats. Dis Model Mech. 2015 Jun;8(6):543-51.

[2]. Yang X, et al. Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells. Oncol Rep. 2013 Feb;29(2):541-8.
Density 0.9±0.1 g/cm3
Boiling Point 186.3±13.0 °C at 760 mmHg
Molecular Formula C3H6N2
Molecular Weight 70.093
Flash Point 66.5±19.8 °C
Exact Mass 70.053101
PSA 49.81000
LogP -1.02
Vapour Pressure 0.7±0.4 mmHg at 25°C
Index of Refraction 1.430

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UG0350000
CHEMICAL NAME :
Propionitrile, 3-amino-
CAS REGISTRY NUMBER :
151-18-8
BEILSTEIN REFERENCE NO. :
1698848
LAST UPDATED :
199701
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C3-H6-N2
MOLECULAR WEIGHT :
70.11
WISWESSER LINE NOTATION :
Z2CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12800 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1152 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg/11D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5 gm/kg
SEX/DURATION :
female 14-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1250 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1250 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - mouse Embryo
DOSE/DURATION :
1250 mg/kg
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 47,305,1981
Hazard Codes Xn:Harmful;
Risk Phrases R20/21/22
Safety Phrases S36/37
RIDADR 3276
RTECS UG0350000
Packaging Group III
Hazard Class 8
HS Code 2926909090
HS Code 2926909090
Summary HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
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