329055-23-4

329055-23-4 structure

Name: Irbesartan hydrochloride
Chemical Name: 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one,hydrochloride
CAS Number: 329055-23-4
Molecular Formula: C₂₅H₂₉ClN₆O
Molecular Weight: 464.99000
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-02-01 20:13:54
Modify Date: 2024-01-14 04:16:10
Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[1].

Name	2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one,hydrochloride
Synonyms	Irbesartan HCl UNII-3OGC31WUMZ Irbesartan hydrochloride 1,3-Diazaspiro(4.4)non-1-en-4-one,2-butyl-3-((2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-,hydrochloride (1:1)

Description	Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
In Vitro	Irbesartan hydrochloride (20 μM, 3 h) reduces Th22 cells chemotaxis in vitro[1]. Irbesartan hydrochloride (0 μM, 20 μM, 40 μM and 60 μM) suppresses Th22 cells differentiation in vitro[1]. Irbesartan hydrochloride (20 μM) inhibits Th22 cells related proinflammatory response of TECs in vitro[1]. Cell Viability Assay[1] Cell Line: CD4+ T cells Concentration: 0, 20, 40 and 60 μM Incubation Time: 48 h Result: Exerted no obvious effect on viability of CD4+T cells.
In Vivo	Irbesartan hydrochloride (oral gavage; 50 mg/kg/d; once daily) reduces Th22 lymphocytosis and serum IL-22 level in Ang II-infused mice[1]. Irbesartan hydrochloride (oral gavage; 50 mg/kg/d; once daily) exerts obvious renoprotective effects[1]. Irbesartan hydrochloride (oral gavage; 50 mg/kg/d; once daily) relieves systemic inflammation and renal fibrosis in hypertension mice induced by Ang II[1]. Irbesartan hydrochloride (20 μM; for 3 h) can attenuate Th22 cells recruitment and IL-22 secretion, which might be through inhibiting chemotaxis in hypertensive renal injury mice[1]. Animal Model: C57BL/6 mice[1] Dosage: 50 mg/kg Administration: oral gavage; 50 mg/kg/d; once daily Result: Displayed low Th22 cells and IL-22, exerted similar inhibitory effect on Th1 cell proportion and displayed decreased IL-22 level in kidney. Prevented BP elevation markedly and decreased urinary albumin/creatinine ratio, BUN and Scr. Repressed the expression of IL-1β, IL-6, TNF-α, α-SMA, FN and Col I and diminished the extent of fibrosis. Animal Model: C57BL/6 mice[1] Dosage: 20 μM Administration: 20 μM; for 3 h Result: Downregulated renal CCL20, CCL22 and CCL27 concentrations.
References	[1]. Yong Zhong, et al. Irbesartan may relieve renal injury by suppressing Th22 cells chemotaxis and infiltration in Ang II-induced hypertension. Int Immunopharmacol

Molecular Formula	C₂₅H₂₉ClN₆O
Molecular Weight	464.99000
Exact Mass	464.20900
PSA	87.13000
LogP	4.95290

Precursor 0
DownStream 1
138402-11-6

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