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Product Name: Anethole trithione
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BioBioPha
China
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China
Product Name: Anethole trithione
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DC Chemicals Limited
China
Product Name: Anethole trithione
Price: $280.0/20mg
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Anethole trithione
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532-11-6

532-11-6 structure

Name: Anethole trithione
Chemical Name: 5-(4-methoxyphenyl)dithiole-3-thione
CAS Number: 532-11-6
Molecular Formula: C₁₀H₈OS₃
Molecular Weight: 240.365
Catalog: API Digestive system medication Biliary medicine
Create Date: 2018-05-30 08:00:00
Modify Date: 2024-01-02 19:21:35
Anethole trithione is a drug used in the treatment of dry mouth， being studied in the treatment of cancer.

Name	5-(4-methoxyphenyl)dithiole-3-thione
Synonyms	Anethole trithione Halpen (p-Methoxyphenyl)trithiopropene EINECS 208-528-5 5-(p-Methoxyphenyl)-1,2-dithiacyclopent-4-ene-3-thione Anetholetrithion 3-(p-Methoxyphenyl)-4,5-dithiacyclopent-2-ene-1-thione Tiotrifar 3-(p-Anisyl)trithione MFCD00129751 Sulfarlem 3H-1,2-Dithiole-3-thione, 5-(4-methoxyphenyl)- Trithio Trithio-p-methoxyphenylpropene Mucinol Heporal 3-(p-Anisyl)-4,5-dithiacyclopent-2-ene-1-thione Tiopropen 5-(4-Methoxyphenyl)-3H-1,2-dithiole-3-thione Sufralem anetholtrithion Felviten Anethole (trithione)

Description	Anethole trithione is a drug used in the treatment of dry mouth， being studied in the treatment of cancer.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer

Density	1.4±0.1 g/cm3
Boiling Point	398.1±52.0 °C at 760 mmHg
Melting Point	23 C
Molecular Formula	C₁₀H₈OS₃
Molecular Weight	240.365
Flash Point	194.6±30.7 °C
Exact Mass	239.973724
PSA	105.50000
LogP	3.39
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.732

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JP1292500

CHEMICAL NAME :: 3H-1,2-Dithiole-3-thione, 5-(p-methoxyphenyl)-

CAS REGISTRY NUMBER :: 532-11-6

BEILSTEIN REFERENCE NO. :: 0158393

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H8-O-S3

MOLECULAR WEIGHT :: 240.36

WISWESSER LINE NOTATION :: T5SSYTJ CUS ER DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 25,815,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,244,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,38,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,25,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,25,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8640 mg/kg/24W-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in adrenal weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 12,79,1976

Hazard Codes	Xi
HS Code	2930909090

104-46-1

532-11-6

Literature: EP1980559 A1, ; Page/Page column 9 ; EP 1980559 A1

4180-23-8

532-11-6

Literature: Justus Liebigs Annalen der Chemie, , vol. 557, p. 89,105 Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 224, p. 479

75-15-0

100-06-1

~89%

532-11-6

Literature: Curphey; Libby Tetrahedron Letters, 2000 , vol. 41, # 36 p. 6977 - 6980

25679-28-1

532-11-6

Literature: EP1645288 A1, ; Page/Page column 5 ;

140-67-0

532-11-6

Literature: Justus Liebigs Annalen der Chemie, , vol. 557, p. 89,105

4180-23-8

532-11-6

77150-78-8

Literature: Justus Liebigs Annalen der Chemie, , vol. 557, p. 89,105 Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 224, p. 479

831-30-1

532-11-6

Literature: Justus Liebigs Annalen der Chemie, , vol. 568, p. 227,237

50849-98-4

532-11-6

Literature: Bulletin de la Societe Chimique de France, , p. 1398,1400

100-06-1

532-11-6

Literature: Bulletin de la Societe Chimique de France, , p. 1398,1400

Precursor 8
104-46-1 4180-23-8 75-15-0 100-06-1
25679-28-1 140-67-0 831-30-1 50849-98-4
DownStream 7
18274-81-2 19652-13-2 100-63-0 1820-42-4
81385-69-5 13232-76-3 4280-58-4

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

532-11-6	18274-81-2
4180-23-8	104-46-1
50770-19-9	25679-28-1
51410-46-9	6308-40-3
15986-33-1	123399-69-9
1158522-08-7	940364-43-2
134104-43-1	131615-57-1
6906-52-1	930439-75-1
10517-45-0	1018584-77-4
2227877-77-0	1375289-11-4