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69388-84-7

69388-84-7 structure
69388-84-7 structure
  • Name: Sulbactam sodium
  • Chemical Name: Sulbactam sodium
  • CAS Number: 69388-84-7
  • Molecular Formula: C8H10NNaO5S
  • Molecular Weight: 255.223
  • Catalog: API Antibiotics Beta-lactamase inhibitor
  • Create Date: 2018-02-07 08:00:00
  • Modify Date: 2026-06-30 17:59:10
  • Sulbactam (CP45899) sodium is a competitive, irreversible beta-lactamase inhibitor. Sulbactam sodium shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex[1][2].
Name Sulbactam sodium
Synonyms 4-thia-1-azabicyclo(3.2.0)htane-2-cboxylicacid,3,3-dimethyl-7-oxo-,4,4-d
SULBACTAM SODIUM
SODIUM SULBACTAM
SulbactaM SodiuM API
penicillanicacid1,1-dioxidesodiumsalt
Sterile Sulbactum Sodium Powder
sodiumsalt,(2s-cis)-ioxid
sodium (2s-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylate 4,4-dioxide
45899sodiumsalt
l^{6}-thia-1-azabicyclo[3.2.0]htane-2-cboxylate
3,3-dimethyl-7-oxo-4,4-dioxide-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic acid, sodium salt (1:1)
Sodium Sodium
sulbacyam sodium
Shu ba sodium
Sulbactam sodium salt, beta-lactamase inhibitor
penicillanicacidsulfonesodiumsalt
sodium1,1-dioxopenicillanate
(2S,5R)
Sulbactam sodium CRS
SULBACTAM SODIUM (NON-STERILE BULK)
AMPICILLIN SODIUM AND SULBACTAM SODIUM 2:1
sodiumpenicillanate1,1-dioxide
sodium Penicillanate 1,1-Dioxide
Sulbactam sodium //BP
sodium (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylate 4,4-dioxide
4-Thia-1-azabicyclo[3.2.0]htane-2-cboxylicacid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, sodium salt, (2S,5R)- (9CI)
Sterile Sulbactam sodium
Antibiotic medicine veteriny sulbactam sodium
sodium 3,3-dimethyl-4,4,7-trioxo-4
Sulbactam sodium - 45899 sodium
SULBACTAM SODIUM SALT
(2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylicacidsodiumsalt4,4-dioxide
SulbactaM SodiuM,USP
Sulbactam sodiumQ: What is Sulbactam sodium Q: What is the CAS Number of Sulbactam sodium Q: What is the storage condition of Sulbactam sodium Q: What e the applications of Sulbactam sodium
penicillanic acid 1,1-dioxide sodium salt
EINECS 273-984-4
penicillanicaciddioxidesodiumsalt
45899-2
Sulbactam sodium, 10 mM in DMSO
Sulbatam Sodium
Penicillanic acid 4,4-dioxide sodium salt
MFCD01750374
Natrium-(2S-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htan-2-cboxylat-4,4-dioxid
(2S-cis)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3,2,0]htane-2-cboxylic acid 4,4-dioxide sodium salt
Description Sulbactam (CP45899) sodium is a competitive, irreversible beta-lactamase inhibitor. Sulbactam sodium shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex[1][2].
Related Catalog
In Vitro Ampicillin-Sulbactam has a wide range of antibacterial activity that includes Gram-positive and Gram-negative aerobic and anaerobic bacteria[3].
References

[1]. Noguchi JK, et al. Sulbactam: a beta-lactamase inhibitor. Clin Pharm. 1988;7(1):37-51.

[2]. Lin HS, et al. Sulbactam treatment for pneumonia involving multidrug-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex. Infect Dis (Lond). 2015;47(6):370-378.

[3]. Betrosian AP, et al. Ampicillin-sulbactam: an update on the use of parenteral and oral forms in bacterial infections. Expert Opin Drug Metab Toxicol. 2009;5(9):1099-1112.
Boiling Point 567.7ºC at 760 mmHg
Melting Point 121-123 °C(lit.)
Molecular Formula C8H10NNaO5S
Molecular Weight 255.223
Flash Point 297.1ºC
Exact Mass 255.017731
PSA 102.96000
Storage condition -20°C Freezer, Under Inert Atmosphere

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XH9220000
CHEMICAL NAME :
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, sodium salt, (2S-cis)-
CAS REGISTRY NUMBER :
69388-84-7
LAST UPDATED :
199512
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C8-H10-N-O2-S.Na
MOLECULAR WEIGHT :
207.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>6 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity)
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>6 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity)
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>6 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity)
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>6 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity)
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 17,1106,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
45500 mg/kg/26W-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18 gm/kg/30D-I
TOXIC EFFECTS :
Gastrointestinal - other changes Liver - other changes Liver - changes in liver weight
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
13500 mg/kg
SEX/DURATION :
female 17-22 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),108,1984
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
13500 mg/kg
SEX/DURATION :
female 17-22 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),108,1984
Hazard Codes Xn: Harmful;
Risk Phrases R42/43
Safety Phrases S26-S37/39
WGK Germany 3
HS Code 2941109900
68373-14-8 structure

68373-14-8

~92%

69388-84-7 structure

69388-84-7

Literature: SANDOZ AG Patent: WO2009/53256 A2, 2009 ; Location in patent: Example 1 ;
762-04-9 structure

762-04-9

76646-91-8 structure

76646-91-8

~77%

69388-84-7 structure

69388-84-7

Literature: Leo Pharmaceutical Products Ltd. A/S Patent: US4816580 A1, 1989 ;
HS Code 2941109900
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