69388-84-7

• 常用中文名：舒巴坦钠
• 常用英文名：Sulbactam sodium
• CAS号：69388-84-7
• 分子式：C₈H₁₀NNaO₅S
• 分子量：255.223
• 相关类别： 原料药 抗生素类药物 β-内酰胺酶抑制剂
• 发布时间：2018-02-07 08:00:00
• 更新时间：2026-06-30 17:59:10
• Sulbactam (CP45899) sodium 是一种竞争性、不可逆的 β-内酰胺酶 (beta-lactamase) 抑制剂。Sulbactam sodium 具有抗菌活性,抑制耐多药不动杆菌-鲍曼不动杆菌复合物。

名称

• 中文名: 舒巴坦钠
• 英文名: Sulbactam sodium
• 中文别名: 舒巴坦钠/A1A; 舒巴坦纳; 舒巴坦钠,舒巴克坦钠,陪他美; 舒巴坦钠(青霉烷砜钠); 舒巴坦钠(标准品); 磺胺钠杂质; 舒巴坦钠杂质; (2S-CIS)-3,3-二甲基-7-氧代-4-硫代-1-氮杂双环[3,2,0]庚烷-2-羧酸4,4-二氧化物钠盐; 舒巴坦鈉; 舒巴坦钠盐; SULBACTAM SODIUM 舒巴坦钠; 舒巴坦钠 非无菌粉 69-7; Sulbactam 舒巴坦钠; Sulbactam Sodium Sterile 舒巴坦钠无菌粉; 青霉烷砜、青霉砜; SULBACTAM SODIUM SALT,BETA-LACTAMASE抑制剂; 舒巴坦钠(无菌); 舒巴坦钠Sulbactam Sodium; 舒巴坦钠 标准品; 舒巴坦钠,10 MM DMSO 溶液; 头孢哌酮+舒巴坦 (1:1); 青霉烷砜钠; (2S,5R)-3,3-二甲基-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-羧酸钠-4,4-二氧化物; 舒巴克坦钠
• 英文别名: 4-thia-1-azabicyclo(3.2.0)htane-2-cboxylicacid,3,3-dimethyl-7-oxo-,4,4-d; SULBACTAM SODIUM; SODIUM SULBACTAM; SulbactaM SodiuM API; penicillanicacid1,1-dioxidesodiumsalt; Sterile Sulbactum Sodium Powder; sodiumsalt,(2s-cis)-ioxid; sodium (2s-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylate 4,4-dioxide; 45899sodiumsalt; l^{6}-thia-1-azabicyclo[3.2.0]htane-2-cboxylate; 3,3-dimethyl-7-oxo-4,4-dioxide-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic acid, sodium salt (1:1); Sodium Sodium; sulbacyam sodium; Shu ba sodium; Sulbactam sodium salt, beta-lactamase inhibitor; penicillanicacidsulfonesodiumsalt; sodium1,1-dioxopenicillanate; (2S,5R); Sulbactam sodium CRS; SULBACTAM SODIUM (NON-STERILE BULK); AMPICILLIN SODIUM AND SULBACTAM SODIUM 2:1; sodiumpenicillanate1,1-dioxide; sodium Penicillanate 1,1-Dioxide; Sulbactam sodium //BP; sodium (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylate 4,4-dioxide; 4-Thia-1-azabicyclo[3.2.0]htane-2-cboxylicacid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, sodium salt, (2S,5R)- (9CI); Sterile Sulbactam sodium; Antibiotic medicine veteriny sulbactam sodium; sodium 3,3-dimethyl-4,4,7-trioxo-4; Sulbactam sodium - 45899 sodium; SULBACTAM SODIUM SALT; (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylicacidsodiumsalt4,4-dioxide; SulbactaM SodiuM,USP; Sulbactam sodiumQ: What is Sulbactam sodium Q: What is the CAS Number of Sulbactam sodium Q: What is the storage condition of Sulbactam sodium Q: What e the applications of Sulbactam sodium; penicillanic acid 1,1-dioxide sodium salt; EINECS 273-984-4; penicillanicaciddioxidesodiumsalt; 45899-2; Sulbactam sodium, 10 mM in DMSO; Sulbatam Sodium; Penicillanic acid 4,4-dioxide sodium salt; MFCD01750374; Natrium-(2S-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htan-2-cboxylat-4,4-dioxid; (2S-cis)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3,2,0]htane-2-cboxylic acid 4,4-dioxide sodium salt

物化性质

• 沸点: 567.7ºC at 760 mmHg
• 熔点: 121-123 °C(lit.)
• 分子式: C₈H₁₀NNaO₅S
• 分子量: 255.223
• 闪点: 297.1ºC
• 精确质量: 255.017731
• PSA: 102.96000
• 外观性状: 白色或灰白色结晶粉末
• 储存条件: -20°C Freezer, Under Inert Atmosphere
• 计算化学:

  1、 疏水参数计算参考值（XlogP）：

  2、 氢键供体数量：0

  3、 氢键受体数量：5

  4、 可旋转化学键数量：1

  5、 拓扑分子极性表面积（TPSA）：94.6

  6、 重原子数量：16

  7、 表面电荷：0

  8、 复杂度：452

  9、 同位素原子数量：0

  10、 确定原子立构中心数量：0

  11、 不确定原子立构中心数量：2

  12、 确定化学键立构中心数量：0

  13、 不确定化学键立构中心数量：0

  14、 共价键单元数量：2

• 更多:

  1. 性状：。

  2. 密度（g/mL,25/4℃）：

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：

  5. 沸点（ºC,常压）：

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：。

生物活性

• 描述: Sulbactam (CP45899) sodium 是一种竞争性、不可逆的 β-内酰胺酶 (beta-lactamase) 抑制剂。Sulbactam sodium 具有抗菌活性,抑制耐多药不动杆菌-鲍曼不动杆菌复合物。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 氨苄西林舒巴坦具有广泛的抗菌活性,包括革兰氏阳性和革兰氏阴性需氧菌和厌氧菌[3]。
• 参考文献:

  [1]. Noguchi JK, et al. Sulbactam: a beta-lactamase inhibitor. Clin Pharm. 1988;7(1):37-51.

  [2]. Lin HS, et al. Sulbactam treatment for pneumonia involving multidrug-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex. Infect Dis (Lond). 2015;47(6):370-378.

  [3]. Betrosian AP, et al. Ampicillin-sulbactam: an update on the use of parenteral and oral forms in bacterial infections. Expert Opin Drug Metab Toxicol. 2009;5(9):1099-1112.

毒性和生态

毒理学数据: 1 、急性毒性：大鼠（腹膜）LD50：＞6mg/kg 大鼠（皮下）LD50：＞6mg/kg 大鼠（静脉）LD50：6,500mg/kg 小鼠（腹膜）LD50：＞6mg/kg 小鼠（皮下）LD50：＞6mg/kg 小鼠（静脉）LD50：8,100μg/kg 由于食盐的LD50是3,000 mg/kg，BPA的急性毒性程度与食盐同。 CHEMICAL IDENTIFICATION RTECS NUMBER : XH9220000 CHEMICAL NAME : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, sodium salt, (2S-cis)- CAS REGISTRY NUMBER : 69388-84-7 LAST UPDATED : 199512 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C8-H10-N-O2-S.Na MOLECULAR WEIGHT : 207.24 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >6 gm/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >6 gm/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6500 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >6 gm/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >6 gm/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 8100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 17,1106,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 45500 mg/kg/26W-I TOXIC EFFECTS : Liver - changes in liver weight REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 18 gm/kg/30D-I TOXIC EFFECTS : Gastrointestinal - other changes Liver - other changes Liver - changes in liver weight REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),97,1984 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 13500 mg/kg SEX/DURATION : female 17-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),108,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 13500 mg/kg SEX/DURATION : female 17-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 32(Suppl 4),108,1984

安全

• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R42/43
• 安全声明 (欧洲): S26-S37/39
• WGK德国: 3
• 海关编码: 2941109900

合成路线

68373-14-8 ~92% 69388-84-7

文献：SANDOZ AG Patent: WO2009/53256 A2, 2009 ; Location in patent: Example 1 ;

762-04-9 76646-91-8 ~77% 69388-84-7

文献：Leo Pharmaceutical Products Ltd. A/S Patent: US4816580 A1, 1989 ;

上下游产品

上游产品  3
68373-14-8 762-04-9 76646-91-8
下游产品  4
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