Shanghai Nianxing Industrial Co., Ltd
China
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: 380843-75-4 Bosutinib
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
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Contact: Anson
Email: info@tianfuchem.com

380843-75-4

380843-75-4 structure

380843-75-4 structure

Name: Bosutinib (SKI-606)
Chemical Name: bosutinib
CAS Number: 380843-75-4
Molecular Formula: C₂₆H₂₉Cl₂N₅O₃
Molecular Weight: 530.446
Catalog: API Antineoplastic agents Tinic antineoplastic agents
Create Date: 2018-06-30 19:19:23
Modify Date: 2026-07-24 12:08:36
Bosutinib is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively.

Name	bosutinib
Synonyms	Bosutinib-13CD3 Bosutinib //BP Bosutinib(TINIBS ) Bosutinib/380-4 Bosulif) Bosulif(bosutinib) T66 BNJ DCN EMR BG DG EO1& HO1 IO3- AT6N DNTJ D1 SKI 606 - Bosutinib BOSUTINIB (SKI-606);SKI-606 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecbonitrile 3-Quinolinecbonitrile, 4-[(2,4-dichloro-5-Methoxyphenyl)amino]-6-Methoxy-7-[3-(4-Methyl-1-piperazinyl)propoxy] 4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile Bosutinib, 10 mM in DMSO BOSUTINIB Bosutinib ( SKI-606 ) 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile SKI-606 WAY-173606 Bosutinib CRS 380-4 Bosutinib Bosutinib(SKI 606) Bosutinib for Bosutinib control 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecbonitrile Bosutinib (SKI-606) Bosutinib Bosutinib for research SKI 606 Bosutinib, (HPLC) Bsutinib Bosutinib formate salt

Description	Bosutinib is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Research Areas >> Cancer
References	[1]. Boschelli DH, et al. Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity. J Med Chem, 2001, 44(23), 3965-3977. [2]. Golas JM, et al. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res, 2003, 63(2), 375-381. [3]. Vultur A, et al. SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. Mol Cancer Ther, 2008, 7(5), 1185-1194. [4]. Golas JM, et al. SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models. Cancer Res, 2005, 65(12), 5358-5364.

Density	1.4±0.1 g/cm3
Boiling Point	649.7±55.0 °C at 760 mmHg
Melting Point	116-120ºC
Molecular Formula	C₂₆H₂₉Cl₂N₅O₃
Molecular Weight	530.446
Flash Point	346.7±31.5 °C
Exact Mass	529.164734
PSA	82.88000
LogP	5.48
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.652
Storage condition	room temp

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319-H413
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	36
Safety Phrases	26
RIDADR	NONH for all modes of transport

Precursor 10
846023-56-1 109-01-3 380844-49-5 5317-33-9
622369-46-4 98446-49-2 366-99-4 622369-40-8
622369-38-4 214470-68-5
DownStream 2
918639-08-4 918639-10-8

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