Bosutinib (SKI-606)

Modify Date: 2024-01-02 12:08:07

Bosutinib (SKI-606) structure	Common Name	Bosutinib (SKI-606)
	CAS Number	380843-75-4	Molecular Weight	530.446
	Density	1.4±0.1 g/cm3	Boiling Point	649.7±55.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₂₉Cl₂N₅O₃	Melting Point	116-120ºC
	MSDS	Chinese USA	Flash Point	346.7±31.5 °C
	Symbol	GHS07	Signal Word	Warning

Use of Bosutinib (SKI-606)

Bosutinib is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively.

Name	bosutinib
Synonym	More Synonyms

Description	Bosutinib is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Research Areas >> Cancer
References	[1]. Boschelli DH, et al. Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity. J Med Chem, 2001, 44(23), 3965-3977. [2]. Golas JM, et al. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res, 2003, 63(2), 375-381. [3]. Vultur A, et al. SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. Mol Cancer Ther, 2008, 7(5), 1185-1194. [4]. Golas JM, et al. SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models. Cancer Res, 2005, 65(12), 5358-5364.

Description

Bosutinib is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively.

Related Catalog

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src

Research Areas >> Cancer

References

[1]. Boschelli DH, et al. Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity. J Med Chem, 2001, 44(23), 3965-3977.

[2]. Golas JM, et al. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res, 2003, 63(2), 375-381.

[3]. Vultur A, et al. SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. Mol Cancer Ther, 2008, 7(5), 1185-1194.

[4]. Golas JM, et al. SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models. Cancer Res, 2005, 65(12), 5358-5364.

Density	1.4±0.1 g/cm3
Boiling Point	649.7±55.0 °C at 760 mmHg
Melting Point	116-120ºC
Molecular Formula	C₂₆H₂₉Cl₂N₅O₃
Molecular Weight	530.446
Flash Point	346.7±31.5 °C
Exact Mass	529.164734
PSA	82.88000
LogP	5.48
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.652
Storage condition	room temp

Bosutinib (SKI-606) MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319-H413
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	36
Safety Phrases	26
RIDADR	NONH for all modes of transport

Precursor 10
CAS#:846023-56-1 2-cyano-N-(2,4-... CAS#:109-01-3 methylpiperazine CAS#:380844-49-5 7-(3-CHLOROPROP... CAS#:5317-33-9 3-(4-Methylpipe...
CAS#:622369-46-4 4-[(2,4-Dichlor... CAS#:98446-49-2 5-Amino-2,4-dic... CAS#:366-99-4 3-Fluoro-4-meth... CAS#:622369-40-8 4-Chlor-7-fluor...
CAS#:622369-38-4 7-FLUORO-6-METH... CAS#:214470-68-5 4-Chloro-7-(3-c...
DownStream 2
CAS#:918639-08-4 bosutinib hydrate CAS#:918639-10-8 4-(2,4-dichloro...

Src Kinase Is the Connecting Player between Protein Kinase A (PKA) Activation and Hyperpolarization through SLO3 Potassium Channel Regulation in Mouse Sperm.

J. Biol. Chem. 290 , 18855-64, (2015)

Plasma membrane hyperpolarization is crucial for mammalian sperm to acquire acrosomal responsiveness during capacitation. Among the signaling events leading to mammalian sperm capacitation, the immedi...

In vitro and in vivo identification of ABCB1 as an efflux transporter of bosutinib.

J. Hematol. Oncol. 8 , 81, (2015)

Bosutinib is a recently approved ABL inhibitor. In spite of the well-documented effectiveness of BCR-ABL inhibitors in treating chronic myeloid leukemia, development of resistance is a continuous clin...

A simple method for the determination of Bosutinib in rat plasma by UPLC-MS/MS.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1004 , 93-7, (2015)

In this work, a simple, sensitive and fast ultra performance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantitative determination of b...

Bosutinib(SKI 606)

3-Quinolinecarbonitrile, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-

4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile

SKI 606

SKI-606

Bosutinib

Bosutinib for research

Bosutinib (SKI-606)

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Bosutinib (SKI-606)

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