179474-81-8
179474-81-8 structure
- Name: prucalopride
- Chemical Name: Prucalopride
- CAS Number: 179474-81-8
- Molecular Formula: C18H26ClN3O3
- Molecular Weight: 367.870
- Catalog: Biochemical Inhibitor Neuronal Signaling 5-HT Receptor Agonist
- Create Date: 2018-02-28 08:00:00
- Modify Date: 2026-07-06 12:20:30
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Prucalopride (R093877) is a drug acting as a selective, high affinity 5-HT4 receptor agonist(pKi=8.6/8.1 for 5-HT4a/4b); >150-fold higher affinity for 5-HT4 receptors than for other receptors.IC50 value: 8.6/8.1 for 5-HT4a/4b(pKi)Target: 5-HT4 receptorPrucalopride is a novel enterokinetic compound and is the first representative of the benzofuran class. Receptor binding data have demonstrated prucalopride's high affinity to both investigated 5-HT(4) receptor isoforms, with mean pK(i) estimates of 8.60 and 8.10 for the human 5-HT(4a) and 5-HT(4b) receptor, respectively. From the 50 other binding assays investigated in this study only the human D(4) receptor (pK(i) 5.63), the mouse 5-HT(3) receptor (pK(i) 5.41) and the human sigma(1) (pK(i) 5.43) have shown measurable affinity, resulting in at least 290-fold selectivity for the 5-HT(4) receptor [1].
| Name | Prucalopride |
|---|---|
| Synonyms |
Prucalopride, min
Resolor R093877 Prucalopride, >= 4-amino-5-chloro-N-[1-(3-methoxypropyl) piperidin-4-yl]-2,3-dihydro-1- benzofuran-7-cboxamide monobutanedioate 4-Amino-5-chloro-2,3-dihydro-N-(1-(3-methoxypropyl)-4-piperidyl)-7-benzofurancboxamide 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancboxamide 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-cboxamide 4-Amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide Prucalopride(R-93877) 4-Amino-5-chloro-N-[1-(3-methoxypropyl)-4-piperidinyl]-2,3-dihydro-1-benzofuran-7-carboxamide 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide PrucaloprideQ: What is Prucalopride Q: What is the CAS Number of Prucalopride Q: What is the storage condition of Prucalopride Q: What e the applications of Prucalopride Prucalopride, 10 mM in DMSO Prucalopride a 5-HT Rector agonist 4-Amino-5-chloro-N-[1-(3-methoxypropyl)-4-piperidyl]-2,3-dihydrobenzofuran-7-cboxamide Prucalopride //BP Prucalopride 13CD3Q: What is Prucalopride 13CD3 Q: What is the CAS Number of Prucalopride 13CD3 Q: What is the storage condition of Prucalopride 13CD3 Q: What e the applications of Prucalopride 13CD3 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-cboxamide 7-BenzofurancboxaMide, 4-amino-5-chloro-2,3-dihydro-N-[1-(3-Methoxypropyl)-4-piperidinyl] Prucalopride (R-108512, R-93877) Unii-0A09iuw5tp |
| Description | Prucalopride (R093877) is a drug acting as a selective, high affinity 5-HT4 receptor agonist(pKi=8.6/8.1 for 5-HT4a/4b); >150-fold higher affinity for 5-HT4 receptors than for other receptors.IC50 value: 8.6/8.1 for 5-HT4a/4b(pKi)Target: 5-HT4 receptorPrucalopride is a novel enterokinetic compound and is the first representative of the benzofuran class. Receptor binding data have demonstrated prucalopride's high affinity to both investigated 5-HT(4) receptor isoforms, with mean pK(i) estimates of 8.60 and 8.10 for the human 5-HT(4a) and 5-HT(4b) receptor, respectively. From the 50 other binding assays investigated in this study only the human D(4) receptor (pK(i) 5.63), the mouse 5-HT(3) receptor (pK(i) 5.41) and the human sigma(1) (pK(i) 5.43) have shown measurable affinity, resulting in at least 290-fold selectivity for the 5-HT(4) receptor [1]. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 481.4±45.0 °C at 760 mmHg |
| Melting Point | 90.7° |
| Molecular Formula | C18H26ClN3O3 |
| Molecular Weight | 367.870 |
| Flash Point | 244.9±28.7 °C |
| Exact Mass | 367.166260 |
| PSA | 76.82000 |
| LogP | 1.44 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.599 |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335-H400 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| RIDADR | UN 3077 9 / PGIII |