60-70-8

• 常用中文名：藜芦胺
• 常用英文名：Veratramine
• CAS号：60-70-8
• 分子式：C₂₇H₃₉NO₂
• 分子量：409.604
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 甲基吡啶
• 发布时间：2018-07-18 13:50:12
• 更新时间：2024-01-02 20:12:57
• Veratramine(NSC17821; NSC23880)是信号转导抑制剂,可作用于肿瘤。

名称

• 中文名: 黎芦碱
• 英文名: Veratramine
• 中文别名: 藜芦胺; (2S,3R,5S)-5-甲基-2-[(1S)-1-[(3S,6AR,11AS,11BR)-2,3,4,6,6A,11,11A,11B-八氢-3-羟基-10,11B-二甲基-1H-苯并[A]芴-9-基]乙基]-3-哌啶醇; 藜芦铵; 黎芦胺
• 英文别名: Veratramine; (3β,23R)-14,15,16,17-Tetradehydroveratraman-3,23-diol; Vreaframine; (3b,23b)-14,15,16,17-Tetradehydroveratraman-3,23-diol; 3-Piperidinol, 5-methyl-2-[(1S)-1-[(3S,6aR,11aS,11bR)-2,3,4,6,6a,11,11a,11b-octahydro-3-hydroxy-10,11b-dimethyl-1H-benzo[a]fluoren-9-yl]ethyl]-, (2S,3R,5S)-; Veratraman-3,23-diol, 14,15,16,17-tetradehydro-, (3β,23β)-; veratraMin

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 565.0±50.0 °C at 760 mmHg
• 熔点: 122-124ºC
• 分子式: C₂₇H₃₉NO₂
• 分子量: 409.604
• 闪点: 86.2±20.7 °C
• 精确质量: 409.298065
• PSA: 52.49000
• LogP: 4.90
• 外观性状: 固体;White to Light yellow powder to crystal
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.601
• 储存条件: <0°C;避免加热
• 水溶解性: 水溶性：微溶；可溶于：甲醇,醇,苯,氯仿

生物活性

• 描述: Veratramine(NSC17821; NSC23880)是信号转导抑制剂,可作用于肿瘤。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
  天然产物 >> 生物碱
• 参考文献:

  [1]. Wang L, et al. Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats. Pharmazie. 2008 Aug;63(8):606-10.

  [2]. Li HJ, et al. Puqienine F, a novel veratramine alkaloid from the bulbs of Fritillaria puqiensis. Chem Pharm Bull (Tokyo). 2006 May;54(5):722-4.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YX5094000 CHEMICAL NAME : Veratramine CAS REGISTRY NUMBER : 60-70-8 BEILSTEIN REFERENCE NO. : 0055515 LAST UPDATED : 199706 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C27-H39-N-O2 MOLECULAR WEIGHT : 409.67 WISWESSER LINE NOTATION : L D6 B566 LU&TTTJ A1 E1 OQ FY1&- BT6MTJ CQ E1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4500 ug/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,89,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 2,418,1953 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 33 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 3,175,1970 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 16700 ug/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 136,1174,1971 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 29 mg/kg SEX/DURATION : female 13-14 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 123,921,1966 *** REVIEWS *** TOXICOLOGY REVIEW LYPHAD Lyon Pharmaceutique. (Medipharly, 12, rue de la Barre, 69002 Lyons, France) V.1- 1950- Volume(issue)/page/year: 26,5,1975