145202-66-0
145202-66-0 structure
- Name: Rizatriptan benzoate
- Chemical Name: Rizatriptan Benzoate
- CAS Number: 145202-66-0
- Molecular Formula: C22H25N5O2
- Molecular Weight: 391.466
- Catalog: Biochemical Inhibitor Neuronal Signaling 5-HT Receptor Agonist
- Create Date: 2018-09-04 22:24:10
- Modify Date: 2026-07-01 19:03:57
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Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.Target: 5-HT1 agonist Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches. It is believed to work by narrowing the blood vessels around the brain. Rizatriptan also reduces the substances in the body, which can also reduce headache pain, nausea, sensitivity to light and sound and other migraine symptoms.Rizatriptan was rapidly absorbed with a median tmax of 1.3 h (range 1-3 h) vs a tmax for sumatriptan of 2.5 h (range 1-4 h, P < 0.001). Administration of either rizatriptan or sumatriptan produced maximal mean elevations of 5-10 mmHg in systolic and diastolic blood pressures without effect on heart rate; the changes occurred sooner following rizatriptan, consistent with more rapid absorption. Both rizatriptan and sumatriptan provoked mild increases in serum growth hormone without any effect on serum prolactin concentrations. The most commonly reported symptom following rizatriptan was drowsiness.
| Name | Rizatriptan Benzoate |
|---|---|
| Synonyms |
Rizatrimptan
3-[2-(Dimethylamino) ethyl]- 5- (1,2,4- triazol-1- ylmethyl) -indole benzoate IP n,n-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1h-indol-3-yl]ethylamine benzoate Rizatriptan benzoate salt Rizatriptan monobenzoate N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine benzoate MK-462 Benzoate 1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-, benzoate (1:1) N,N-Dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine benzoate (1:1) Rizatriptan Benzoate > Maxalt Rizatriptan Benzoat N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H Rizatriptan benzoate CRS N,N-DIMETHYL-5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOLE-3-ETHANAMINE, BENZOATE Rizatrimptan Benzoate Rizatriptan (as benzoate) RIZATRIPTANE BENZOATE Rizatrimptan benzoate RIZATRIPTAN BENZOATE (NON-STERILE DRUG SUBSTANCE) N,N-diméthyl-2-[5-(1H-1,2,4-triazol-1-ylméthyl)-1H-indol-3-yl]éthanamine benzoate N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine Benzoate Rizatriptan benzoateQ: What is Rizatriptan benzoate Q: What is the CAS Number of Rizatriptan benzoate Q: What is the storage condition of Rizatriptan benzoate Q: What e the applications of Rizatriptan benzoate Rizatriptani benzoas 2-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethan-1-amine benzoate MK-0462 2-(5-((1H-1,2,4-triazol-1-yl)Methyl)-1H-indol-3-yl)-N,N-diMethylethanaMine benzoate N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine monobenzoate Rizatriptan benzoate N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine benzoate Rizatriptan benzoate API Acid Bixente triptans N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine,benzoate (1:1) RIZATRIPTAN BENZOATE Rizatriptan benzoate,MaxaLt MK-462 (N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine benzoate salt MFCD00866224 Rizatriptan API MK-462 Rizatriptan for system suitability Rizatriptan Impurity6 N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine benzoate salt Rizatriptan benzoate, 10 mM in DMSO MAXALT Rizatriptan for system suitability CRS Rizatriptan Benzoate (MK-462 Benzoate) Benzolcarbonsäure--N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamin(1:1) Rizatriptan Rizatriptan benzoate //BP N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-ethanamine benzoate (1:1) |
| Description | Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.Target: 5-HT1 agonist Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches. It is believed to work by narrowing the blood vessels around the brain. Rizatriptan also reduces the substances in the body, which can also reduce headache pain, nausea, sensitivity to light and sound and other migraine symptoms.Rizatriptan was rapidly absorbed with a median tmax of 1.3 h (range 1-3 h) vs a tmax for sumatriptan of 2.5 h (range 1-4 h, P < 0.001). Administration of either rizatriptan or sumatriptan produced maximal mean elevations of 5-10 mmHg in systolic and diastolic blood pressures without effect on heart rate; the changes occurred sooner following rizatriptan, consistent with more rapid absorption. Both rizatriptan and sumatriptan provoked mild increases in serum growth hormone without any effect on serum prolactin concentrations. The most commonly reported symptom following rizatriptan was drowsiness. |
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| Related Catalog | |
| References |
| Density | 1.21g/cm3 |
|---|---|
| Boiling Point | 504.8ºC at 760mmHg |
| Melting Point | 178-180°C |
| Molecular Formula | C22H25N5O2 |
| Molecular Weight | 391.466 |
| Flash Point | 259.1ºC |
| Exact Mass | 391.200836 |
| PSA | 87.04000 |
| LogP | 3.29660 |
| Vapour Pressure | 2.58E-10mmHg at 25°C |
| Index of Refraction | 1.645 |
| Storage condition | -20°C Freezer |
| Symbol |
GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H360 |
| Precautionary Statements | P201-P280-P308 + P313 |
| Hazard Codes | C,Xi |
| Risk Phrases | R34:Causes burns. |
| Safety Phrases | S26-S36/37/39-S45 |
| RIDADR | 3259 |
| HS Code | 2933990090 |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |