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115256-11-6

115256-11-6 structure
115256-11-6 structure
  • Name: Dofetilide
  • Chemical Name: dofetilide
  • CAS Number: 115256-11-6
  • Molecular Formula: C19H27N3O5S2
  • Molecular Weight: 441.565
  • Catalog: API Circulatory system medication Antiarrhythmic drug
  • Create Date: 2018-06-07 18:36:31
  • Modify Date: 2026-07-03 21:35:53
  • Dofetilide(Tikosyn) is a class III antiarrhythmic agent.Target: Potassium ChannelIn patients with congestive heart failure and reduced left ventricular function, dofetilide was effective in converting atrial fibrillation, preventing its recurrence, and reducing the risk of hospitalization for worsening heart failure. Dofetilide had no effect on mortality [1]. dofetilide preferentially blocks open (or activated) channels and that the fast inactivation may competitively slow the binding kinetics. Dofetilide acts as a slow-onset/slow-offset open channel blocker of this current at nanomolar concentrations [2].
Name dofetilide
Synonyms beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide
Dofetilide - Bio-X
DofetilideQ: What is Dofetilide Q: What is the CAS Number of Dofetilide Q: What is the storage condition of Dofetilide Q: What e the applications of Dofetilide
DOFETILIDE
Tikosyn：UK-68798
beta-((p-methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidid
N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide
Dofetilide //BP
n-[4-(2-{2-[4-(methanesulphonamido)phenoxyl]-n-methylethylamino}ethyl)phenyl]-methanesulphonamide
UK-68798
N-[4-[2-[2-[4-(methanesulfonamido)phenyl]ethyl-methyl-amino]ethoxy]phenyl]methanesulfonamide
Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl) phenyl)
Dofetilide Impurity
Tikosy
U-68798
Dofetilide, 10 mM in DMSO
Dofetilide, >=
1-MSPMPE
methanesulfonamide,n-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)a
b-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide
N-(4-{2-[Methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide
N-[4-[2-[N-Methyl-2-(4-methylsulfonylaminophenoxy)ethylamino]ethyl]phenyl]methanesulfonamide
Dofetilide, hERG K+ channel blocker
N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide
N-[4-[2-[2-[4-(methanesulfonamido)phenyl]ethyl-methylamino]ethoxy]phenyl]methanesulfonamide
N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfon Amide
N-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide
Methyl[2-[4-(methylsulfonylamino)phenoxy]ethyl][4-(methylsulfonylamino)phenethyl]amine
Xelide
N-[4-[2-[methyl-[2-[4-(methylsulfonylamino)phenyl]ethyl]amino]ethoxy]phenyl]methanesulfonamide
1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane
1-(4-MethanesulphonaMidophenoxy)-2-[N-(4-MethanesulphonaMidophen
dofetilida
A little more
Dofetilidum
MFCD00869707
mino)ethyl)phenyl)
Tikosym
Dofetilida
Tikosyn
Description Dofetilide(Tikosyn) is a class III antiarrhythmic agent.Target: Potassium ChannelIn patients with congestive heart failure and reduced left ventricular function, dofetilide was effective in converting atrial fibrillation, preventing its recurrence, and reducing the risk of hospitalization for worsening heart failure. Dofetilide had no effect on mortality [1]. dofetilide preferentially blocks open (or activated) channels and that the fast inactivation may competitively slow the binding kinetics. Dofetilide acts as a slow-onset/slow-offset open channel blocker of this current at nanomolar concentrations [2].
Related Catalog
References

[1]. Maisch, B., et al., [Pregnancy and cardiomyopathies]. Herz, 2003. 28(3): p. 196-208.

[2]. Snyders, D.J. and A. Chaudhary, High affinity open channel block by dofetilide of HERG expressed in a human cell line. Mol Pharmacol, 1996. 49(6): p. 949-55.
Density 1.3±0.1 g/cm3
Boiling Point 614.1±65.0 °C at 760 mmHg
Melting Point 147-1490C
Molecular Formula C19H27N3O5S2
Molecular Weight 441.565
Flash Point 325.2±34.3 °C
Exact Mass 441.139221
PSA 121.57000
LogP 1.56
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.614
Storage condition Store at RT

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PB0478000
CHEMICAL NAME :
Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)e thyl)amino)ethyl) phenyl)-
CAS REGISTRY NUMBER :
115256-11-6
LAST UPDATED :
199806
DATA ITEMS CITED :
3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
22050 ug/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 53,168,1996
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
11025 ug/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 53,168,1996
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
44100 ug/kg
SEX/DURATION :
female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 53,168,1996
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H302-H360
Precautionary Statements P201-P308 + P313
Hazard Codes Xi
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases 26-37/39
RIDADR NONH for all modes of transport
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