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148244-82-0

148244-82-0 structure
148244-82-0 structure
  • Name: Secoisolariciresinol Diglucoside
  • Chemical Name: Seco-isolariciresinol diglucoside
  • CAS Number: 148244-82-0
  • Molecular Formula: C32H50O18
  • Molecular Weight: 722.73
  • Catalog: Biochemical Carbohydrate Double sugar
  • Create Date: 2018-04-08 08:00:00
  • Modify Date: 2024-01-05 13:31:19
  • seco-Isolariciresinol Diglucoside, a synthetic lignin, which is derived from the natural plant flaxseed. seco-Isolariciresinol Diglucoside reduces asbestos-induced NLRP3 expression, and NF-κB activation in macrophages (MF). seco-Isolariciresinol Diglucoside also activates Nrf2.
Name Seco-isolariciresinol diglucoside
Synonyms β-D-Glucopyranoside, (2R,3R)-4-(β-D-glucopyranosyloxy)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]butyl
(2R,3R)-4-(β-D-Glucopyranosyloxy)-2,3-bis(4-hydroxy-3-methoxybenzyl)butyl β-D-glucopyranoside
SecoisolariciresinolDiglucoside
Flaxseed Extract
Secoisolariciresinol Diglucosi
Secoisolariciresinol diglucoside
Description seco-Isolariciresinol Diglucoside, a synthetic lignin, which is derived from the natural plant flaxseed. seco-Isolariciresinol Diglucoside reduces asbestos-induced NLRP3 expression, and NF-κB activation in macrophages (MF). seco-Isolariciresinol Diglucoside also activates Nrf2.
Related Catalog
Target

NLRP3

NF-κB

Nrf2

In Vitro seco-Isolariciresinol Diglucoside (LGM2605) is a nontoxic lignan with anti-inflammatory and antioxidant properties and is evaluated for protection from asbestos in murine peritoneal macrophages (MF). seco-Isolariciresinol Diglucoside significantly reduces NLRP3 ranging from 40 to 81%, IL-1β by 89-96%, and TNFα by 67-78%, as well as activated NF-κB by 48-49% while decreasing levels of nitrates/nitrites by 85-93%. seco-Isolariciresinol Diglucoside reduces asbestos-induced NLRP3 expression, proinflammatory cytokine release, NF-κB activation, and nitrosative stress in macrophages (MF) supporting its possible use in preventing the asbestos-induced inflammatory cascade leading to malignancy. seco-Isolariciresinol Diglucoside inhibits NF-κB expression and prevents asbestos-induced iNOS expression and nitric oxide production by murine peritoneal macrophages. seco-Isolariciresinol Diglucoside activates Nrf2 and induces the expression of cellular antioxidant and detoxification enzymes[1].
References

[1]. Pietrofesa RA, et al. The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages. Oxid Med Cell Longev. 2017;2017:7395238.
Density 1.5±0.1 g/cm3
Boiling Point 989.2±65.0 °C at 760 mmHg
Molecular Formula C32H50O18
Molecular Weight 722.73
Flash Point 552.0±34.3 °C
PSA 257.68000
LogP -2.79
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.655
Storage condition 2-8°C
RIDADR NONH for all modes of transport
HS Code 2932999099
HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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title: CAS No. 148244-82-0 | Chemsrc address: https://m.chemsrc.com/en/baike/895576.html

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