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557-04-0

557-04-0 structure
557-04-0 structure
  • Name: Magnesium stearate
  • Chemical Name: magnesium distearate
  • CAS Number: 557-04-0
  • Molecular Formula: C36H70MgO4
  • Molecular Weight: 591.24
  • Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Chloropyridine
  • Create Date: 2018-07-30 12:06:17
  • Modify Date: 2026-07-09 02:19:26
  • Magnesium stearate is a commonly used pharmaceutical lubricant. But Magnesium stearate leads to an adverse effect on bonding between particles. Magnesium stearate can be used as an excipient, such as lubricant. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Name magnesium distearate
Synonyms MagnesiuM steate ., Meets analytical specification of Ph.Eur., BP, >= steic and palMitic acid basis, >= steic acid basis , Mg basis (calc on dry sub.)
Bis(octadecanoic acid)magnesium salt
MAGNESIUM STEATE N.F
synpro 90
Stearic acid, magnesium salt
Anti-C4d-A
Steic Acid Magnesium(II) Salt
magnesiumdisteate
MAGNESIUM STEARATE (E-470B, F.C.C.) ADITIO
MAGNESIUMSTEATE,NF,BP,JP
stearic acid magnesium salt
Magnesiumdisteat
Magnesium Steate, from Plants
STEIC ACID, MAGNESIUM SALT
Magnesiumsteatemedicinal
Magnesium Steate, 3.0um
stearatedemagnesium
MAGENSIUM STEARATE
MAGNESIUMSTEARATE
MEGNESIUM STEATATE
dibasicmagnesiumsteate
Octadecanoicacid, MagnesiuM salt (2:1)
MAGNESIUM STEARATE API
magnesiumdistearate
Synpro Magnesium Stearate 90
OCTADECANOIC ACID MAGNESIUM SALT
MAGNESIUMSTEATE,FCC
MAGNESIUM OCTADECANOATE
stearic acid,magnesium stearate
CoMpleMent C4d-A proteinantibody
Magnesium Steate in stock Factory
MAGNESIUM STEATE EXTRA DAB, PH. E UR., B.P., PH. FRANC
MAGNESIUM STEATE EXTRA PHMACOPOEIA
Magnesium Steate ExiPlus, Multi-Compendial
Magnesium steate,Steic acid magnesium salt
Bis(steic acid) magnesium
MAGNESIUMSTEARATE,FCC
petracmg20nf
nesium steate
Magnesium steate ade
MagnesiuM steates
Magnesium steate ISO 9001：2015 REACH
Disteic acid magnesium
OCTADECONIC ACID MAGNESIUM SALT
MAGNESIUM DISTEARATE
STEIC ACID MAGNESIUM SALT
MFCD00036391
MAGNESIUM STEATE NF/FCC
Magnesium Steate Veg. NF
Magnesium Steate , Kosher
EINECS 209-150-3
Magnesium steate
Octadecanoic acid, magnesium salt
Octadecanoic acid, magnesium salt (2:1)
Magnesium(II) Steate
MAGNESIUMSTEARATEBP
MagnesiumSteatrecipitated
Bissteic acid magnesium
Magnesium dioctadecanoate
Microcrystalline cellulose use as the oral steroid filler
Dibasic magnesium stearate
Magnesium steate, Mg
Synpro Magnesium Steate 90
stearate magnesium
Magnesium Steate Bp
Magnesiumdistearat
MAGNESIUM STEARATE NF
magnesium sterate
Dolomol
food additive magnesium steate
Magnesium steate, extra , Ph Eur, BP
C4d-A
MagnesiuM Steate (AS)
Magnesiumstearat
OCTADECANOICACID, MAGNESIUM SALT (2:1)
MAGNESIUM OCTADECANOATE Manufacturer
Magnesium steate, magnesium
MAGENSIUM STEATE
MAGNESIUM STEARATE, FCC
Magnesium Stearate Bp
MagnesiuM steate API
steatedemagnesium
Description Magnesium stearate is a commonly used pharmaceutical lubricant. But Magnesium stearate leads to an adverse effect on bonding between particles. Magnesium stearate can be used as an excipient, such as lubricant. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog
References

[1]. Zuurman K, et al. Effect of magnesium stearate on bonding and porosity expansion of tablets produced from materials with different consolidation properties[J]. International journal of pharmaceutics, 1999, 179(1): 107-115.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

Density 1.028g/cm3
Boiling Point 359.4ºC at 760mmHg
Melting Point 200 °C(lit.)
Molecular Formula C36H70MgO4
Molecular Weight 591.24
Flash Point 162.4ºC
Exact Mass 590.512451
PSA 52.60000
LogP 12.50830
Index of Refraction 1.45 (25ºC)
Storage condition Store at RT.
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility Insoluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WI4390000
CHEMICAL NAME :
Stearic acid, magnesium salt
CAS REGISTRY NUMBER :
557-04-0
LAST UPDATED :
199712
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C36-H70-O4.Mg

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1092 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 17,51,1980 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81884 No. of Facilities: 2092 (estimated) No. of Industries: 19 No. of Occupations: 34 No. of Employees: 31116 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6914 No. of Facilities: 64 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 320 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81884 No. of Facilities: 5057 (estimated) No. of Industries: 57 No. of Occupations: 78 No. of Employees: 184994 (estimated) No. of Female Employees: 101129 (estimated)
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany -
RTECS WI4390000
HS Code 29157030
69-65-8 structure

69-65-8

~%

557-04-0 structure

557-04-0

Literature: US2014/100236 A1, ; Page/Page column ;
Precursor  1

DownStream  2

HS Code 29157030
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