Magnesium stearate

Modify Date: 2024-01-02 17:13:07

Magnesium stearate structure	Common Name	Magnesium stearate
	CAS Number	557-04-0	Molecular Weight	591.24
	Density	1.028g/cm3	Boiling Point	359.4ºC at 760mmHg
	Molecular Formula	C₃₆H₇₀MgO₄	Melting Point	200 °C(lit.)
	MSDS	Chinese USA	Flash Point	162.4ºC

Use of Magnesium stearate

Magnesium stearate is a commonly used pharmaceutical lubricant. But Magnesium stearate leads to an adverse effect on bonding between particles. Magnesium stearate can be used as an excipient, such as lubricant. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

Name	magnesium distearate
Synonym	More Synonyms

Description	Magnesium stearate is a commonly used pharmaceutical lubricant. But Magnesium stearate leads to an adverse effect on bonding between particles. Magnesium stearate can be used as an excipient, such as lubricant. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Zuurman K, et al. Effect of magnesium stearate on bonding and porosity expansion of tablets produced from materials with different consolidation properties[J]. International journal of pharmaceutics, 1999, 179(1): 107-115. [2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Description

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Zuurman K, et al. Effect of magnesium stearate on bonding and porosity expansion of tablets produced from materials with different consolidation properties[J]. International journal of pharmaceutics, 1999, 179(1): 107-115.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Density	1.028g/cm3
Boiling Point	359.4ºC at 760mmHg
Melting Point	200 °C(lit.)
Molecular Formula	C₃₆H₇₀MgO₄
Molecular Weight	591.24
Flash Point	162.4ºC
Exact Mass	590.512451
PSA	52.60000
LogP	12.50830
Index of Refraction	1.45 (25ºC)
Storage condition	Store at RT.
Stability	Stable. Incompatible with strong oxidizing agents.
Water Solubility	Insoluble

Magnesium stearate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WI4390000

CHEMICAL NAME :: Stearic acid, magnesium salt

CAS REGISTRY NUMBER :: 557-04-0

LAST UPDATED :: 199712

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C36-H70-O4.Mg

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1092 gm/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 17,51,1980 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81884 No. of Facilities: 2092 (estimated) No. of Industries: 19 No. of Occupations: 34 No. of Employees: 31116 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6914 No. of Facilities: 64 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 320 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81884 No. of Facilities: 5057 (estimated) No. of Industries: 57 No. of Occupations: 78 No. of Employees: 184994 (estimated) No. of Female Employees: 101129 (estimated)

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	-
RTECS	WI4390000
HS Code	29157030

D-Mannitol

CAS#:69-65-8

Magnesium stearate

CAS#:557-04-0

Literature: US2014/100236 A1, ; Page/Page column ;

Precursor 1
CAS#:69-65-8 D-Mannitol
DownStream 2
CAS#:39133-31-8 Trimebutine CAS#:5638-76-6 Betahistine

HS Code	29157030

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Magnesium stearate
Price: Click To Check
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Magnesium stearate
Price: ￥88.0/500g
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Magnesium stearate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
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Delivery: Inquiry
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Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: magnesium distearate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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