30211-77-9

30211-77-9 structure

Name: 2-Nitro-5-thiocyanatobenzoic Acid
Chemical Name: 2-nitro-5-thiocyanatobenzoic acid
CAS Number: 30211-77-9
Molecular Formula: C₈H₄N₂O₄S
Molecular Weight: 224.19300
Catalog: Chemical reagent Organic reagent Aromatic acid
Create Date: 2018-04-03 08:00:00
Modify Date: 2025-08-27 14:52:11
2-Nitro-5-thiocyanatobenzoic acid (NTCB) is a highly reactive reagent that transfers its cyano group rapidly to a nucleophilic thiolate. 2-Nitro-5-thiocyanatobenzoic acid has been proposed as a reagent for converting thiol groups in proteins into their S-cyano derivatives[1][2].

Name	2-nitro-5-thiocyanatobenzoic acid
Synonyms	NTCB MFCD00007139 2-Nitro-5-thiocyanatobenzoesaeure EINECS 250-093-9 2-Nitro-5-thiocyanobenzoic acid,NTCB 2-Nitro-5-thiocyanobenzoic acid 2-Nitro-5-thiocyano-benzoesaeure Benzoic acid,2-nitro-5-thiocyanato

Description	2-Nitro-5-thiocyanatobenzoic acid (NTCB) is a highly reactive reagent that transfers its cyano group rapidly to a nucleophilic thiolate. 2-Nitro-5-thiocyanatobenzoic acid has been proposed as a reagent for converting thiol groups in proteins into their S-cyano derivatives[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	2-Nitro-5-thiocyanatobenzoic acid（NTCB is a highly reactive reagent that transfers its cyano group rapidly to a nucleophilic thiolate. When it is provided to a protein, it will quickly cyanylate the protein cysteine to form S-cyano-cysteine which undergoes reversible intramolecular addition with the cysteine N-amide to generate 1-acyl-2-iminothiazolidine, an intermediate that can undergo nucleophilic acyl substitution[1].
References	[1]. Qiao Y, et al. Site-Specific Conversion of Cysteine in a Protein to Dehydroalanine Using 2-Nitro-5-thiocyanatobenzoic Acid. Molecules. 2021;26(9):2619. Published 2021 Apr 29. [2]. Price NC. Alternative products in the reaction of 2-nitro-5-thiocyanatobenzoic acid with thiol groups. Biochem J. 1976;159(1):177-180.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2930909090

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%