Name | 2-nitro-5-thiocyanatobenzoic acid |
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Synonyms |
NTCB
MFCD00007139 2-Nitro-5-thiocyanatobenzoesaeure EINECS 250-093-9 2-Nitro-5-thiocyanobenzoic acid,NTCB 2-Nitro-5-thiocyanobenzoic acid 2-Nitro-5-thiocyano-benzoesaeure Benzoic acid,2-nitro-5-thiocyanato |
Description | 2-Nitro-5-thiocyanatobenzoic acid (NTCB) is a highly reactive reagent that transfers its cyano group rapidly to a nucleophilic thiolate. 2-Nitro-5-thiocyanatobenzoic acid has been proposed as a reagent for converting thiol groups in proteins into their S-cyano derivatives[1][2]. |
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Related Catalog | |
In Vitro | 2-Nitro-5-thiocyanatobenzoic acid(NTCB is a highly reactive reagent that transfers its cyano group rapidly to a nucleophilic thiolate. When it is provided to a protein, it will quickly cyanylate the protein cysteine to form S-cyano-cysteine which undergoes reversible intramolecular addition with the cysteine N-amide to generate 1-acyl-2-iminothiazolidine, an intermediate that can undergo nucleophilic acyl substitution[1]. |
References |
Density | 1.63g/cm3 |
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Boiling Point | 449ºC at 760mmHg |
Melting Point | 156-157ºC(lit.) |
Molecular Formula | C8H4N2O4S |
Molecular Weight | 224.19300 |
Flash Point | 225.4ºC |
Exact Mass | 223.98900 |
PSA | 132.21000 |
LogP | 2.38938 |
Appearance | powder | yellow |
Index of Refraction | 1.5690 (estimate) |
Storage condition | 2-8°C |
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi: Irritant; |
Risk Phrases | 36/37/38 |
Safety Phrases | 26-36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
HS Code | 2930909090 |
Precursor 2 | |
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DownStream 1 | |
HS Code | 2930909090 |
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Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |