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144689-24-7

144689-24-7 structure
144689-24-7 structure
Name olmesartan
Synonyms 4-(2-Hydroxy-2-propanyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylic acid
Olmesartan Acid
MFCD00914967
Olmesartan
5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
Description Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.
Related Catalog
In Vivo Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks[1]. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species[2].
Animal Admin Seven week-old male spontaneously hypertensive rats (SHR) are divided into five groups and fed a high fat diet (HFD) (60% kcal as fat) ad libitum. SHR are treated with vehicle (1% tragacanth gum solution), telmisartan (1 mg/kg), telmisartan (2 mg/kg), olmesartan (1 mg/kg) or olmesartan (2 mg/kg) once daily by gastric gavage. After more than 4 weeks-treatment, mean arterial blood pressure is measured for 24 h under a conscious state.
References

[1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7.

[2]. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67(6):503-9.

[3]. Komiya H, et al. Sleep/wakefulness behaviors in mice during pregnancy and pregnancy-associated hypertensive mice. Sleep. 2018 Mar 1;41(3).
Density 1.3±0.1 g/cm3
Boiling Point 738.3±70.0 °C at 760 mmHg
Melting Point 186-188ºC
Molecular Formula C24H26N6O3
Molecular Weight 446.502
Flash Point 400.3±35.7 °C
Exact Mass 446.206635
PSA 129.81000
LogP 3.72
Vapour Pressure 0.0±2.6 mmHg at 25°C
Index of Refraction 1.671
Storage condition -20°C Freezer
Hazard Codes Xi
RIDADR NONH for all modes of transport
RTECS NI4014100
HS Code 2921590090
HS Code 2921590090
Summary 2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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